Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study
Objective Some patients with dengue fever tend to develop thrombocytopenia during the course of infection and are thus vulnerable to haemorrhagic manifestations and other complications. However, the factors associated with the development of thrombocytopenia are unknown. We aimed to identify factors...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e035120.full |
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| author | Marcus T Silva Luciane Cruz Lopes Izabela Fulone Bruna M Castilho André R R Freitas |
| author_facet | Marcus T Silva Luciane Cruz Lopes Izabela Fulone Bruna M Castilho André R R Freitas |
| author_sort | Marcus T Silva |
| collection | DOAJ |
| description | Objective Some patients with dengue fever tend to develop thrombocytopenia during the course of infection and are thus vulnerable to haemorrhagic manifestations and other complications. However, the factors associated with the development of thrombocytopenia are unknown. We aimed to identify factors associated with an increased risk of thrombocytopenia and haematological changes in patients with confirmed dengue fever.Design Retrospective cohort study.Setting Brazilian multicentre primary care databases.Participants 387 patients had positive laboratory serological confirmation of dengue infection during 2014. The data were identified from two databases: Notification of Injury Information System (SINAN) and Municipal Laboratory.Main outcome measure The presence of thrombocytopenia (platelet count <1 50×109/L). The associations of factors that predisposed patients to thrombocytopenia and haematological changes were analysed using logistic regression. ORs and 95% CIs were calculated.Results Among 387 patients, 156 had both dengue and thrombocytopenia. The risk factors associated with thrombocytopenia included male sex (OR: 1.77, 95% CI: 1.16 to 2.71, p=0.007), age of 46–64 years (OR: 2.20, 95% CI: 1.15 to 4.21, p=0.009) or ≥65 years (OR: 3.02, 95% CI: 1.40 to 6.50, p=0.002), presence of leucopenia (OR: 6.85, 95% CI: 4.27 to 10.99, p<0.001) and high mean corpuscular haemoglobin (MCH) levels (OR: 2.00, 95% CI: 1.29 to 3.12, p=0.005).Conclusion Older age, male sex, presence of leucopenia and high MCH levels were identified as risk factors associated with the development of thrombocytopenia in this population. |
| format | Article |
| id | doaj-art-8b9a64064e1043a7974a779c194ac220 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8b9a64064e1043a7974a779c194ac2202025-01-07T12:50:08ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-035120Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort studyMarcus T Silva0Luciane Cruz Lopes1Izabela Fulone2Bruna M Castilho3André R R Freitas4Pharmaceutical Sciences Graduate Course, University of Sorocaba (UNISO), Sorocaba, São Paulo, BrazilGraduate Course in Pharmaceutical Sciences, University of Sorocaba, Sorocaba (SP), BrazilPharmaceutical Science, University of Sorocaba, Sorocaba, BrazilSchool of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, BrazilFaculdade São Leopoldo Mandic, Campinas, São Paulo, BrazilObjective Some patients with dengue fever tend to develop thrombocytopenia during the course of infection and are thus vulnerable to haemorrhagic manifestations and other complications. However, the factors associated with the development of thrombocytopenia are unknown. We aimed to identify factors associated with an increased risk of thrombocytopenia and haematological changes in patients with confirmed dengue fever.Design Retrospective cohort study.Setting Brazilian multicentre primary care databases.Participants 387 patients had positive laboratory serological confirmation of dengue infection during 2014. The data were identified from two databases: Notification of Injury Information System (SINAN) and Municipal Laboratory.Main outcome measure The presence of thrombocytopenia (platelet count <1 50×109/L). The associations of factors that predisposed patients to thrombocytopenia and haematological changes were analysed using logistic regression. ORs and 95% CIs were calculated.Results Among 387 patients, 156 had both dengue and thrombocytopenia. The risk factors associated with thrombocytopenia included male sex (OR: 1.77, 95% CI: 1.16 to 2.71, p=0.007), age of 46–64 years (OR: 2.20, 95% CI: 1.15 to 4.21, p=0.009) or ≥65 years (OR: 3.02, 95% CI: 1.40 to 6.50, p=0.002), presence of leucopenia (OR: 6.85, 95% CI: 4.27 to 10.99, p<0.001) and high mean corpuscular haemoglobin (MCH) levels (OR: 2.00, 95% CI: 1.29 to 3.12, p=0.005).Conclusion Older age, male sex, presence of leucopenia and high MCH levels were identified as risk factors associated with the development of thrombocytopenia in this population.https://bmjopen.bmj.com/content/10/9/e035120.full |
| spellingShingle | Marcus T Silva Luciane Cruz Lopes Izabela Fulone Bruna M Castilho André R R Freitas Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study BMJ Open |
| title | Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study |
| title_full | Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study |
| title_fullStr | Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study |
| title_full_unstemmed | Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study |
| title_short | Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study |
| title_sort | factors associated with thrombocytopenia in patients with dengue fever a retrospective cohort study |
| url | https://bmjopen.bmj.com/content/10/9/e035120.full |
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