Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function

Background The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors indicating the need for adequately tuning CAR T cell functionality.Methods We leveraged a translational pipeline including biophys...

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Main Authors: Arpad Szoor, Gyorgy Vereb, Hinrich Abken, Markus Barden, Patrick Ronan Elsenbroich, Vivian Haas, Moritz Ertelt, Philip Pervan, Lukas Velas, Bence Gergely, Dennis Christoph Harrer, Valerie Bezler, Astrid Holzinger, Rasmus Ulslev Wegener Friis, Gerhard J Schütz, Clara T Schoeder, Andreas A Hombach
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/12/e010208.full
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https://jitc.bmj.com/content/12/12/e010208.full

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