Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria
Background: Altered microbiota has been implicated in the pathogenesis of chronic spontaneous urticaria (CSU). However, studies showing the effects of probiotic supplementation in CSU are scarce. Objectives: The objective of the study was to evaluate the efficacy of oral probiotic supplementation (L...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Dermatologica Sinica |
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| Online Access: | https://journals.lww.com/10.4103/ds.DS-D-24-00136 |
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| author | Pelin Kuteyla Can Utkan Kızıltaç Kübra Cüre Ralfi Singer Ece Nur Degirmentepe Emek Kocaturk |
| author_facet | Pelin Kuteyla Can Utkan Kızıltaç Kübra Cüre Ralfi Singer Ece Nur Degirmentepe Emek Kocaturk |
| author_sort | Pelin Kuteyla Can |
| collection | DOAJ |
| description | Background:
Altered microbiota has been implicated in the pathogenesis of chronic spontaneous urticaria (CSU). However, studies showing the effects of probiotic supplementation in CSU are scarce.
Objectives:
The objective of the study was to evaluate the efficacy of oral probiotic supplementation (Lactobacillus reuteri) in patients with CSU.
Methods:
This was a prospective, nonrandomized, parallel group, and controlled study. Oral probiotic supplementation (L. reuteri ATCC 55730 1 × 108 CFU) and a single dose of ebastine were introduced to 30 CSU patients, whereas a control group of 30 CSU patients received only a single dose of ebastine. Treatment responses, symptom control, and quality of life (QoL) were evaluated with Urticaria Activity Score 7 (UAS7), Physicians’ Global Assessment Visual Analog Score (PhyGA-VAS), and Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) at weeks 0, 2, and 4.
Results:
There were significant decreases in the UAS7 and CU-Q2oL and increases in PhyGA-VAS both in the probiotic group and control group at weeks 2 and 4 (P < 0.05; for all). The changes in the UAS7, CU-Q2oL, and PhyGA-VAS were significantly higher in the probiotic group than in the control group (P = 0.026; P = 0.001; and P = 0.004). The number of responders was significantly higher in the probiotic group than in the control group (83.3% vs. 50%, P = 0.006). Complete response and significant clinical improvement were observed in 9 (30%) and 20 (66.7%) patients in the probiotic group and 6 (20%) and 12 (40%) patients in the control group, respectively. High levels of total immunoglobulin E (≥100 IU/mL) were more frequent in probiotic nonresponders than in probiotic responders.
Conclusion:
Probiotics, when added to the standard therapy may improve the symptoms as well as the QoL scores in the treatment of CSU. |
| format | Article |
| id | doaj-art-8b5f0dac80084b008694df9269eaef0b |
| institution | Kabale University |
| issn | 1027-8117 2223-330X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj-art-8b5f0dac80084b008694df9269eaef0b2024-12-06T06:31:24ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172223-330X2024-11-0142428028610.4103/ds.DS-D-24-00136Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticariaPelin Kuteyla CanUtkan KızıltaçKübra CüreRalfi SingerEce Nur DegirmentepeEmek KocaturkBackground: Altered microbiota has been implicated in the pathogenesis of chronic spontaneous urticaria (CSU). However, studies showing the effects of probiotic supplementation in CSU are scarce. Objectives: The objective of the study was to evaluate the efficacy of oral probiotic supplementation (Lactobacillus reuteri) in patients with CSU. Methods: This was a prospective, nonrandomized, parallel group, and controlled study. Oral probiotic supplementation (L. reuteri ATCC 55730 1 × 108 CFU) and a single dose of ebastine were introduced to 30 CSU patients, whereas a control group of 30 CSU patients received only a single dose of ebastine. Treatment responses, symptom control, and quality of life (QoL) were evaluated with Urticaria Activity Score 7 (UAS7), Physicians’ Global Assessment Visual Analog Score (PhyGA-VAS), and Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) at weeks 0, 2, and 4. Results: There were significant decreases in the UAS7 and CU-Q2oL and increases in PhyGA-VAS both in the probiotic group and control group at weeks 2 and 4 (P < 0.05; for all). The changes in the UAS7, CU-Q2oL, and PhyGA-VAS were significantly higher in the probiotic group than in the control group (P = 0.026; P = 0.001; and P = 0.004). The number of responders was significantly higher in the probiotic group than in the control group (83.3% vs. 50%, P = 0.006). Complete response and significant clinical improvement were observed in 9 (30%) and 20 (66.7%) patients in the probiotic group and 6 (20%) and 12 (40%) patients in the control group, respectively. High levels of total immunoglobulin E (≥100 IU/mL) were more frequent in probiotic nonresponders than in probiotic responders. Conclusion: Probiotics, when added to the standard therapy may improve the symptoms as well as the QoL scores in the treatment of CSU.https://journals.lww.com/10.4103/ds.DS-D-24-00136chronic spontaneous urticarialactobacillus reuterimicrobiomeprobiotic supplementationprobioticsurticaria treatment |
| spellingShingle | Pelin Kuteyla Can Utkan Kızıltaç Kübra Cüre Ralfi Singer Ece Nur Degirmentepe Emek Kocaturk Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria Dermatologica Sinica chronic spontaneous urticaria lactobacillus reuteri microbiome probiotic supplementation probiotics urticaria treatment |
| title | Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria |
| title_full | Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria |
| title_fullStr | Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria |
| title_full_unstemmed | Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria |
| title_short | Evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria |
| title_sort | evaluation of the effect of adding probiotic supplementation in patients with chronic spontaneous urticaria |
| topic | chronic spontaneous urticaria lactobacillus reuteri microbiome probiotic supplementation probiotics urticaria treatment |
| url | https://journals.lww.com/10.4103/ds.DS-D-24-00136 |
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