Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study
Background Botulinum toxin type A is widely used to improve facial wrinkles associated with aging, and various types are available. However, the efficacy, particularly the duration of effect, varies among these types, and research on this subject is limited. This study aimed to compare the efficacy...
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Korean Society for Aesthetic Plastic Surgery
2024-07-01
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| Series: | Archives of Aesthetic Plastic Surgery |
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| Online Access: | http://e-aaps.org/upload/pdf/aaps-2024-01172.pdf |
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| author | Jong Hun Lee Seo Koo Lee Sang Hun Kim Sun Jae Lee Jun Hyun Kim Eun Soo Park |
| author_facet | Jong Hun Lee Seo Koo Lee Sang Hun Kim Sun Jae Lee Jun Hyun Kim Eun Soo Park |
| author_sort | Jong Hun Lee |
| collection | DOAJ |
| description | Background Botulinum toxin type A is widely used to improve facial wrinkles associated with aging, and various types are available. However, the efficacy, particularly the duration of effect, varies among these types, and research on this subject is limited. This study aimed to compare the efficacy and safety of incobotulinum toxin A and abobotulinum toxin A. Methods This prospective analysis included cases of moderate to severe glabellar lines treated with either incobotulinum toxin A or abobotulinum toxin A. After a 24-week follow-up, clinical photos were taken at each visit. The severity of the glabellar lines was evaluated by three groups: the investigator, the patients, and an independent evaluator. Results The study included a total of 42 patients. When comparing the improvement rates of glabellar lines at maximum frown for both groups at the week-4 visit, which was the primary efficacy endpoint, no statistically significant difference was observed. However, the abobotulinum toxin A group demonstrated a higher improvement at the week-24 visit, as evaluated by the investigator, and this difference was statistically significant. Conclusions Overall, the abobotulinum toxin A group exhibited a higher improvement rate in the glabellar lines at the frown state. The difference in the improvement rate at the week-24 visit was 36.86%, which was statistically significant. |
| format | Article |
| id | doaj-art-8b5085cd72c74bb7b2d7cc065ea9c080 |
| institution | Kabale University |
| issn | 2234-0831 2288-9337 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Korean Society for Aesthetic Plastic Surgery |
| record_format | Article |
| series | Archives of Aesthetic Plastic Surgery |
| spelling | doaj-art-8b5085cd72c74bb7b2d7cc065ea9c0802024-11-18T07:29:18ZengKorean Society for Aesthetic Plastic SurgeryArchives of Aesthetic Plastic Surgery2234-08312288-93372024-07-0130310110710.14730/aaps.2024.01172847Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized studyJong Hun Lee0Seo Koo Lee1Sang Hun Kim2Sun Jae Lee3Jun Hyun Kim4Eun Soo Park5 Department of Plastic and Reconstructive Surgery, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, KoreaBackground Botulinum toxin type A is widely used to improve facial wrinkles associated with aging, and various types are available. However, the efficacy, particularly the duration of effect, varies among these types, and research on this subject is limited. This study aimed to compare the efficacy and safety of incobotulinum toxin A and abobotulinum toxin A. Methods This prospective analysis included cases of moderate to severe glabellar lines treated with either incobotulinum toxin A or abobotulinum toxin A. After a 24-week follow-up, clinical photos were taken at each visit. The severity of the glabellar lines was evaluated by three groups: the investigator, the patients, and an independent evaluator. Results The study included a total of 42 patients. When comparing the improvement rates of glabellar lines at maximum frown for both groups at the week-4 visit, which was the primary efficacy endpoint, no statistically significant difference was observed. However, the abobotulinum toxin A group demonstrated a higher improvement at the week-24 visit, as evaluated by the investigator, and this difference was statistically significant. Conclusions Overall, the abobotulinum toxin A group exhibited a higher improvement rate in the glabellar lines at the frown state. The difference in the improvement rate at the week-24 visit was 36.86%, which was statistically significant.http://e-aaps.org/upload/pdf/aaps-2024-01172.pdfbotulinum toxinsskin agingabobotulinumtoxinaincobotulinumtoxina |
| spellingShingle | Jong Hun Lee Seo Koo Lee Sang Hun Kim Sun Jae Lee Jun Hyun Kim Eun Soo Park Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study Archives of Aesthetic Plastic Surgery botulinum toxins skin aging abobotulinumtoxina incobotulinumtoxina |
| title | Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study |
| title_full | Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study |
| title_fullStr | Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study |
| title_full_unstemmed | Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study |
| title_short | Comparing the efficacy, safety, and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin A and incobotulinum toxin A: a multicenter randomized study |
| title_sort | comparing the efficacy safety and satisfaction for moderate to severe glabellar frown lines between abobotulinum toxin a and incobotulinum toxin a a multicenter randomized study |
| topic | botulinum toxins skin aging abobotulinumtoxina incobotulinumtoxina |
| url | http://e-aaps.org/upload/pdf/aaps-2024-01172.pdf |
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