PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

Background: It has been reported that loss of PCBP2 led to increased reactive oxygen species (ROS) production and accelerated cell aging. Knockdown of PCBP2 in HCT116 cells leads to significant downregulation of fibroblast growth factor 2 (FGF2). Here, we tried to elucidate the intrinsic factors and...

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Bibliographic Details
Main Authors: Pengbo Chen, Bo Li, Zeyu Lu, Qingyin Xu, Huoliang Zheng, Shengdan Jiang, Leisheng Jiang, Xinfeng Zheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
osteoporosis
senescence
hBMSCs
PCBP2
ROS
FGF2
Online Access:https://elifesciences.org/articles/92419
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