The expression of BHLHE22 in endometrial carcinoma: Associations with mismatch repair protein expression status, tumor-infiltrating immune cells, programmed death-ligand 1 and clinical outcomes

The expression of BHLHE22 in endometrial carcinoma: Associations with mismatch repair protein expression status, tumor-infiltrating immune cells, programmed death-ligand 1 and clinical outcomes

Objective: Endometrial cancer (EC) shows substantial heterogeneity in their immune microenvironment. BHLHE22 is consistently hypermethylated in EC and high expression of BHLHE22 is likely to be immunosuppressive in the tumor microenvironment. Herein, we evaluated expression of BHLHE22, programmed ce...

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Bibliographic Details
Main Authors: Lin-Yu Chen, Hsing-Yu Chen, Hung-Cheng Lai, Shiou-Fu Lin, Kuo-Chang Wen, Darmawi, Phui-Ly Liew
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Subjects:
BHLHE22
Endometrial cancer
PD-L1
Survival
Tumor-infiltrating immune cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455924002857
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