Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis
The antibiotic resistance of Bacteria Vaginosis (BV) isolates intensifies vaginal morbidity and genital infections facilitating poor treatment outcome and severe vaginal pathology. The phytochemicals in Ocimum sanctum essential oil (OsEO) were investigated for their antibacterial activity against ba...
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Elsevier
2024-12-01
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| Series: | Medicine in Microecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097824000181 |
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| author | Paul Akinniyi Akinduti Oluwashindara Lydia Osunlola Feyisikemi Adenike Adebekun David Temiloluwa Viavonu Gift Nzubechi Elughi Oluwasegun Popoola Somrat Adeola Abdulsalami |
| author_facet | Paul Akinniyi Akinduti Oluwashindara Lydia Osunlola Feyisikemi Adenike Adebekun David Temiloluwa Viavonu Gift Nzubechi Elughi Oluwasegun Popoola Somrat Adeola Abdulsalami |
| author_sort | Paul Akinniyi Akinduti |
| collection | DOAJ |
| description | The antibiotic resistance of Bacteria Vaginosis (BV) isolates intensifies vaginal morbidity and genital infections facilitating poor treatment outcome and severe vaginal pathology. The phytochemicals in Ocimum sanctum essential oil (OsEO) were investigated for their antibacterial activity against bacteria vaginosis and major metabolites on multidrug resistance (MDR) strains. Bacteria pathogens isolated from vaginal samples (n = 40) obtained from patients with confirmed BV were analysed for hemolytic activity, biofilm production and profiled for antibiotic resistance. Extracted OsEO was profiled with GC-MS and analysed for antibacterial activity. Of the recovered bacteria pathogens (n = 241) associated with vaginosis including Streptococcus pyogenes (34 %), Staphylococcus aureus (31 %) and Escherichia coli (10 %) and less than 10 % Klebsiella oxytoca, Enterobacter cloaca, Pseudomonas aeruginosa and Citrobacter freundii were identified. Significant rates of 21.6 %, 4.6 % and 2.3 % were weak, mild and strong biofilm producers respectively and overall 26.6 % were hemolytic strains (p < 0.05). More than 60 % resistance to ceftriaxone sulbactam, ampiclox, cefuroxime, cefotaxime, nalidixic acid and cefexime was observed in BV with significant proportion showing MARI>0.2 (p < 0.05). Hierarchical clustering of MDR BV strains provided related clustered bacteria pathogens having a very low susceptibility to iminepem, cefuroxime, and amoxycillin/clavulanate. More than 1.2 % saponin, alkaloids and flavonoids levels in OsEO gave significant inhibitory activities at IC50 (25.0 μg/mL) and IC90 (50.0 μg/mL) and significant inhibitory association with phytochemical compounds (eta = 0.457, p = 0.015). OsEO cyclohexene and methanoazulene metabolites showed significant antibacterial association with BV strains (p < 0.05). The OsEO phytochemical metabolites showed antibacterial activity against multidrug resistance BV and identified cyclohexene and methanoazulene are promising candidates for developing formulations as topical antimicrobial agents for BV treatment. |
| format | Article |
| id | doaj-art-8ae61df9b0b04d2f8c3fe5442e94a970 |
| institution | Kabale University |
| issn | 2590-0978 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Medicine in Microecology |
| spelling | doaj-art-8ae61df9b0b04d2f8c3fe5442e94a9702024-12-06T05:14:19ZengElsevierMedicine in Microecology2590-09782024-12-0122100115Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosisPaul Akinniyi Akinduti0Oluwashindara Lydia Osunlola1Feyisikemi Adenike Adebekun2David Temiloluwa Viavonu3Gift Nzubechi Elughi4Oluwasegun Popoola5Somrat Adeola Abdulsalami6Department of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, Nigeria; Corresponding author.Department of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, NigeriaDepartment of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, NigeriaDepartment of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, NigeriaDepartment of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, NigeriaGolden Gate University School of Law, San Francisco, CA, USADepartment of Aquaculture and Fisheries, University of Ilorin, Ilorin Kwara State, NigeriaThe antibiotic resistance of Bacteria Vaginosis (BV) isolates intensifies vaginal morbidity and genital infections facilitating poor treatment outcome and severe vaginal pathology. The phytochemicals in Ocimum sanctum essential oil (OsEO) were investigated for their antibacterial activity against bacteria vaginosis and major metabolites on multidrug resistance (MDR) strains. Bacteria pathogens isolated from vaginal samples (n = 40) obtained from patients with confirmed BV were analysed for hemolytic activity, biofilm production and profiled for antibiotic resistance. Extracted OsEO was profiled with GC-MS and analysed for antibacterial activity. Of the recovered bacteria pathogens (n = 241) associated with vaginosis including Streptococcus pyogenes (34 %), Staphylococcus aureus (31 %) and Escherichia coli (10 %) and less than 10 % Klebsiella oxytoca, Enterobacter cloaca, Pseudomonas aeruginosa and Citrobacter freundii were identified. Significant rates of 21.6 %, 4.6 % and 2.3 % were weak, mild and strong biofilm producers respectively and overall 26.6 % were hemolytic strains (p < 0.05). More than 60 % resistance to ceftriaxone sulbactam, ampiclox, cefuroxime, cefotaxime, nalidixic acid and cefexime was observed in BV with significant proportion showing MARI>0.2 (p < 0.05). Hierarchical clustering of MDR BV strains provided related clustered bacteria pathogens having a very low susceptibility to iminepem, cefuroxime, and amoxycillin/clavulanate. More than 1.2 % saponin, alkaloids and flavonoids levels in OsEO gave significant inhibitory activities at IC50 (25.0 μg/mL) and IC90 (50.0 μg/mL) and significant inhibitory association with phytochemical compounds (eta = 0.457, p = 0.015). OsEO cyclohexene and methanoazulene metabolites showed significant antibacterial association with BV strains (p < 0.05). The OsEO phytochemical metabolites showed antibacterial activity against multidrug resistance BV and identified cyclohexene and methanoazulene are promising candidates for developing formulations as topical antimicrobial agents for BV treatment.http://www.sciencedirect.com/science/article/pii/S2590097824000181Bacteria vaginosisMultidrug resistanceAntibacterial activityPhytochemicalsMetabolites |
| spellingShingle | Paul Akinniyi Akinduti Oluwashindara Lydia Osunlola Feyisikemi Adenike Adebekun David Temiloluwa Viavonu Gift Nzubechi Elughi Oluwasegun Popoola Somrat Adeola Abdulsalami Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis Medicine in Microecology Bacteria vaginosis Multidrug resistance Antibacterial activity Phytochemicals Metabolites |
| title | Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis |
| title_full | Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis |
| title_fullStr | Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis |
| title_full_unstemmed | Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis |
| title_short | Antibacterial activity of Ocimum sanctum L. essential oil against multidrug resistance bacteria vaginosis |
| title_sort | antibacterial activity of ocimum sanctum l essential oil against multidrug resistance bacteria vaginosis |
| topic | Bacteria vaginosis Multidrug resistance Antibacterial activity Phytochemicals Metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S2590097824000181 |
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