More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration
Magnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, and biodegradability. In this study, we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/...
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KeAi Communications Co., Ltd.
2024-11-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724001075 |
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| author | Sihui Ouyang Xiong Wu Li Meng Xuerui Jing Liying Qiao Jia She Kai Zheng Xianhua Chen Fusheng Pan |
| author_facet | Sihui Ouyang Xiong Wu Li Meng Xuerui Jing Liying Qiao Jia She Kai Zheng Xianhua Chen Fusheng Pan |
| author_sort | Sihui Ouyang |
| collection | DOAJ |
| description | Magnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, and biodegradability. In this study, we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/GTR membranes, showcasing their in vitro antibacterial effects, cell migration, and osteogenic differentiation abilities. Mg-Ag alloys with different Ag contents were engineered to facilitate the cell migration of murine fibroblasts (L929) and the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs). The Mg-Ag alloy consisted of recrystallized α-Mg grains and fine Mg4Ag second phases, with an observable refinement in the average grain size to 5.6 µm with increasing Ag content. Among the alloys, Mg-9Ag exhibited optimal mechanical strength and moderate plasticity (tensile yield strength of 205.7 MPa, elongation of 20.3%, and a maximum bending load of 437.2 N). Furthermore, the alloying of Ag accelerated the cathodic reaction of pure Mg, leading to a slightly increased corrosion rate of the Mg-Ag alloys while maintaining acceptable general corrosion. Notably, compared with pure Mg, Mg-Ag alloys had superior antibacterial effects against Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). Taken together, these results provide evidence for the significant clinical potential of Mg-Ag alloys as GBR/GTR membranes. |
| format | Article |
| id | doaj-art-8abc6c8e099240cb871f8ff60da9a85b |
| institution | Kabale University |
| issn | 2213-9567 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-8abc6c8e099240cb871f8ff60da9a85b2025-01-05T04:28:03ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672024-11-01121144544467More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regenerationSihui Ouyang0Xiong Wu1Li Meng2Xuerui Jing3Liying Qiao4Jia She5Kai Zheng6Xianhua Chen7Fusheng Pan8College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing, 400044, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, ChinaJiangsu Key Laboratory of Oral Diseases & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing, 400044, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing, 400044, China; Corresponding authors.Jiangsu Key Laboratory of Oral Diseases & Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China; Corresponding authors.College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing, 400044, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; National Key Laboratory of Advanced Casting Technologies, Chongqing University, Chongqing, 400044, ChinaMagnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, and biodegradability. In this study, we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/GTR membranes, showcasing their in vitro antibacterial effects, cell migration, and osteogenic differentiation abilities. Mg-Ag alloys with different Ag contents were engineered to facilitate the cell migration of murine fibroblasts (L929) and the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs). The Mg-Ag alloy consisted of recrystallized α-Mg grains and fine Mg4Ag second phases, with an observable refinement in the average grain size to 5.6 µm with increasing Ag content. Among the alloys, Mg-9Ag exhibited optimal mechanical strength and moderate plasticity (tensile yield strength of 205.7 MPa, elongation of 20.3%, and a maximum bending load of 437.2 N). Furthermore, the alloying of Ag accelerated the cathodic reaction of pure Mg, leading to a slightly increased corrosion rate of the Mg-Ag alloys while maintaining acceptable general corrosion. Notably, compared with pure Mg, Mg-Ag alloys had superior antibacterial effects against Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). Taken together, these results provide evidence for the significant clinical potential of Mg-Ag alloys as GBR/GTR membranes.http://www.sciencedirect.com/science/article/pii/S2213956724001075BiodegradableMagnesium alloyAntibacterialGuided tissue regenerationGuided bone regeneration |
| spellingShingle | Sihui Ouyang Xiong Wu Li Meng Xuerui Jing Liying Qiao Jia She Kai Zheng Xianhua Chen Fusheng Pan More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration Journal of Magnesium and Alloys Biodegradable Magnesium alloy Antibacterial Guided tissue regeneration Guided bone regeneration |
| title | More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration |
| title_full | More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration |
| title_fullStr | More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration |
| title_full_unstemmed | More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration |
| title_short | More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration |
| title_sort | more than the barrier effect biodegradable mg ag alloy membranes for guided bone tissue regeneration |
| topic | Biodegradable Magnesium alloy Antibacterial Guided tissue regeneration Guided bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724001075 |
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