More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration
Magnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, and biodegradability. In this study, we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-11-01
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| Series: | Journal of Magnesium and Alloys |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724001075 |
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| Summary: | Magnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, and biodegradability. In this study, we present a pioneering application of Mg-Ag alloys featuring tunable corrosion behaviors for GBR/GTR membranes, showcasing their in vitro antibacterial effects, cell migration, and osteogenic differentiation abilities. Mg-Ag alloys with different Ag contents were engineered to facilitate the cell migration of murine fibroblasts (L929) and the osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs). The Mg-Ag alloy consisted of recrystallized α-Mg grains and fine Mg4Ag second phases, with an observable refinement in the average grain size to 5.6 µm with increasing Ag content. Among the alloys, Mg-9Ag exhibited optimal mechanical strength and moderate plasticity (tensile yield strength of 205.7 MPa, elongation of 20.3%, and a maximum bending load of 437.2 N). Furthermore, the alloying of Ag accelerated the cathodic reaction of pure Mg, leading to a slightly increased corrosion rate of the Mg-Ag alloys while maintaining acceptable general corrosion. Notably, compared with pure Mg, Mg-Ag alloys had superior antibacterial effects against Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). Taken together, these results provide evidence for the significant clinical potential of Mg-Ag alloys as GBR/GTR membranes. |
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| ISSN: | 2213-9567 |