CXCL8 modulates M0 macrophage proliferation and polarization to influence tumor progression in cervical cancer

CXCL8 modulates M0 macrophage proliferation and polarization to influence tumor progression in cervical cancer

Abstract Cervical cancer (CESC) presents significant clinical challenges due to its complex tumor microenvironment (TME) and varied treatment responses. This study identified undifferentiated M0 macrophages as high-risk immune cells critically involved in CESC progression. Co-culture experiments fur...

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Bibliographic Details
Main Authors: Xiyan Zhao, Li Yang, Jigang Pan, Zhirui Zeng, Tuo Zhang, Yushi Yang, Jingjing Zhang, Tengxiang Chen, Ziwen Xiao, Wei Pan
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Cervical cancer (CESC)
M0 macrophages
CXCL8
tumor microenvironment (TME)
Single-cell RNA sequencing (scRNA-seq)
Online Access:https://doi.org/10.1038/s41598-024-81726-y
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