Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation
Purpose Radiomics may aid in predicting prognosis in patients with colorectal liver metastases (CLM). Consistent data is available on CT, yet limited data is available on MRI. This study assesses the capability of MRI-derived radiomic features (RFs) to predict local tumor progression-free survival (...
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| Format: | Article |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2349059 |
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| author | Angelo Della Corte Martina Mori Francesca Calabrese Diego Palumbo Francesca Ratti Gabriele Palazzo Alessandro Pellegrini Domenico Santangelo Monica Ronzoni Emiliano Spezi Antonella Del Vecchio Claudio Fiorino Luca Aldrighetti Francesco De Cobelli |
| author_facet | Angelo Della Corte Martina Mori Francesca Calabrese Diego Palumbo Francesca Ratti Gabriele Palazzo Alessandro Pellegrini Domenico Santangelo Monica Ronzoni Emiliano Spezi Antonella Del Vecchio Claudio Fiorino Luca Aldrighetti Francesco De Cobelli |
| author_sort | Angelo Della Corte |
| collection | DOAJ |
| description | Purpose Radiomics may aid in predicting prognosis in patients with colorectal liver metastases (CLM). Consistent data is available on CT, yet limited data is available on MRI. This study assesses the capability of MRI-derived radiomic features (RFs) to predict local tumor progression-free survival (LTPFS) in patients with CLMs treated with microwave ablation (MWA).Methods All CLM patients with pre-operative Gadoxetic acid-MRI treated with MWA in a single institution between September 2015 and February 2022 were evaluated. Pre-procedural information was retrieved retrospectively. Two observers manually segmented CLMs on T2 and T1-Hepatobiliary phase (T1-HBP) scans. After inter-observer variability testing, 148/182 RFs showed robustness on T1-HBP, and 141/182 on T2 (ICC > 0.7).Cox multivariate analysis was run to establish clinical (CLIN-mod), radiomic (RAD-T1, RAD-T2), and combined (COMB-T1, COMB-T2) models for LTPFS prediction.Results Seventy-six CLMs (43 patients) were assessed. Median follow-up was 14 months. LTP occurred in 19 lesions (25%).CLIN-mod was composed of minimal ablation margins (MAMs), intra-segment progression and primary tumor grade and exhibited moderately high discriminatory power in predicting LTPFS (AUC = 0.89, p = 0.0001). Both RAD-T1 and RAD-T2 were able to predict LTPFS: (RAD-T1: AUC = 0.83, p = 0.0003; RAD-T2: AUC = 0.79, p = 0.001). Combined models yielded the strongest performance (COMB-T1: AUC = 0.98, p = 0.0001; COMB-T2: AUC = 0.95, p = 0.0003). Both combined models included MAMs and tumor regression grade; COMB-T1 also featured 10th percentile of signal intensity, while tumor flatness was present in COMB-T2.Conclusion MRI-based radiomic evaluation of CLMs is feasible and potentially useful for LTP prediction. Combined models outperformed clinical or radiomic models alone for LTPFS prediction. |
| format | Article |
| id | doaj-art-8a549b7747cb4d01a9ba242ac7defa47 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-8a549b7747cb4d01a9ba242ac7defa472025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2349059Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablationAngelo Della Corte0Martina Mori1Francesca Calabrese2Diego Palumbo3Francesca Ratti4Gabriele Palazzo5Alessandro Pellegrini6Domenico Santangelo7Monica Ronzoni8Emiliano Spezi9Antonella Del Vecchio10Claudio Fiorino11Luca Aldrighetti12Francesco De Cobelli13Department of Radiology, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Medical Physics, San Raffaele Scientific Institute, Milan, ItalyDepartment of Radiology, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Radiology, IRCCS San Raffaele Hospital, Milan, ItalyHepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Medical Physics, San Raffaele Scientific Institute, Milan, ItalyDepartment of Radiology, IRCCS San Raffaele Hospital, Milan, ItalyDepartment of Radiology, IRCCS San Raffaele Hospital, Milan, ItalyUnit of Oncology, IRCCS San Raffaele Scientific Institute, Milan, ItalySchool of Engineering, Cardiff University, Cardiff, UKDepartment of Medical Physics, San Raffaele Scientific Institute, Milan, ItalyDepartment of Medical Physics, San Raffaele Scientific Institute, Milan, ItalyUniversity Vita-Salute San Raffaele, Milan, ItalyDepartment of Radiology, IRCCS San Raffaele Hospital, Milan, ItalyPurpose Radiomics may aid in predicting prognosis in patients with colorectal liver metastases (CLM). Consistent data is available on CT, yet limited data is available on MRI. This study assesses the capability of MRI-derived radiomic features (RFs) to predict local tumor progression-free survival (LTPFS) in patients with CLMs treated with microwave ablation (MWA).Methods All CLM patients with pre-operative Gadoxetic acid-MRI treated with MWA in a single institution between September 2015 and February 2022 were evaluated. Pre-procedural information was retrieved retrospectively. Two observers manually segmented CLMs on T2 and T1-Hepatobiliary phase (T1-HBP) scans. After inter-observer variability testing, 148/182 RFs showed robustness on T1-HBP, and 141/182 on T2 (ICC > 0.7).Cox multivariate analysis was run to establish clinical (CLIN-mod), radiomic (RAD-T1, RAD-T2), and combined (COMB-T1, COMB-T2) models for LTPFS prediction.Results Seventy-six CLMs (43 patients) were assessed. Median follow-up was 14 months. LTP occurred in 19 lesions (25%).CLIN-mod was composed of minimal ablation margins (MAMs), intra-segment progression and primary tumor grade and exhibited moderately high discriminatory power in predicting LTPFS (AUC = 0.89, p = 0.0001). Both RAD-T1 and RAD-T2 were able to predict LTPFS: (RAD-T1: AUC = 0.83, p = 0.0003; RAD-T2: AUC = 0.79, p = 0.001). Combined models yielded the strongest performance (COMB-T1: AUC = 0.98, p = 0.0001; COMB-T2: AUC = 0.95, p = 0.0003). Both combined models included MAMs and tumor regression grade; COMB-T1 also featured 10th percentile of signal intensity, while tumor flatness was present in COMB-T2.Conclusion MRI-based radiomic evaluation of CLMs is feasible and potentially useful for LTP prediction. Combined models outperformed clinical or radiomic models alone for LTPFS prediction.https://www.tandfonline.com/doi/10.1080/02656736.2024.2349059Livermetastasismagnetic resonance imagingablationprecision medicine |
| spellingShingle | Angelo Della Corte Martina Mori Francesca Calabrese Diego Palumbo Francesca Ratti Gabriele Palazzo Alessandro Pellegrini Domenico Santangelo Monica Ronzoni Emiliano Spezi Antonella Del Vecchio Claudio Fiorino Luca Aldrighetti Francesco De Cobelli Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation International Journal of Hyperthermia Liver metastasis magnetic resonance imaging ablation precision medicine |
| title | Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation |
| title_full | Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation |
| title_fullStr | Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation |
| title_full_unstemmed | Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation |
| title_short | Preoperative MRI radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation |
| title_sort | preoperative mri radiomic analysis for predicting local tumor progression in colorectal liver metastases before microwave ablation |
| topic | Liver metastasis magnetic resonance imaging ablation precision medicine |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2349059 |
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