Structural mechanism of strand exchange by the RAD51 filament

Structural mechanism of strand exchange by the RAD51 filament

Homologous recombination (HR) preserves genomic stability by repairing double-strand DNA breaks and ensuring efficient DNA replication. Central to HR is the strand-exchange reaction taking place within the three-stranded synapsis wherein a RAD51 nucleoprotein filament binds to a donor DNA. Here, we...

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Bibliographic Details
Main Authors: Luay Joudeh, Robert E Appleby, Joseph D Maman, Luca Pellegrini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
DNA repair
homologous recombination
RAD51
D-loop
cryoEM
Online Access:https://elifesciences.org/articles/107114
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https://elifesciences.org/articles/107114

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