Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats
Banana (Musa paradiasiaca var. sapientum) is the world's most popular fruit-bearing crop, with rising consumption and waste. This study aimed to measure the metabolite compound and evaluate the gastroprotective properties of a banana peel-purified methanol extract. Animals test used in this st...
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| Format: | Article |
| Language: | English |
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Universitas Ahmad Dahlan
2024-11-01
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| Series: | Pharmaciana |
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| Online Access: | https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/27639 |
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| author | Jastria Pusmarani Risky Juliansyah Putri Citra Dewi Difa Fitriani Setyo Purwono Zullies Ikawati |
| author_facet | Jastria Pusmarani Risky Juliansyah Putri Citra Dewi Difa Fitriani Setyo Purwono Zullies Ikawati |
| author_sort | Jastria Pusmarani |
| collection | DOAJ |
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Banana (Musa paradiasiaca var. sapientum) is the world's most popular fruit-bearing crop, with rising consumption and waste. This study aimed to measure the metabolite compound and evaluate the gastroprotective properties of a banana peel-purified methanol extract. Animals test used in this study were divided into six groups: Group One received NaCMC 0.5%, Group Two received sucralfate, Group Three received aspirin 1000 mg/kg body weight, and groups four, five, and six received PBP at doses of 200 mg/kg body weight, 400 mg/kg body weight, and 600 mg/kg body weight, respectively, for seven days. Except for group 1, all groups were induced with aspirin at 1000 mg/kg body weight on the eighth day. The result of this study exhibited banana peel containing total phenolic, flavonoid, and tannin compounds with concentrations of 33.45 mg GAE/g, 19.92 mg QE/g, and 0.16 %, respectively. The results showed that pure extract of Musa paradiasiaca var. sapientum fruit peel can reduce the incidence of gastric ulcers by decreasing the ulcer index (p<0.05).. The results suggested that Musa paradisiaca var. sapientum peel has a gastroprotective effect against aspirin-induced gastric ulceration.
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| format | Article |
| id | doaj-art-8a17481b013241f6a36114f6bd9959d1 |
| institution | Kabale University |
| issn | 2088-4559 2477-0256 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj-art-8a17481b013241f6a36114f6bd9959d12025-01-12T00:37:13ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562024-11-0114310.12928/pharmaciana.v14i3.2763919992Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in RatsJastria PusmaraniRisky Juliansyah Putri0Citra Dewi1Difa Fitriani2Setyo Purwono3Zullies Ikawati4Universitas Mandala WaluyaUniversitas Mandala WaluyaUniversitas Mandala WaluyaUniversitas Gadjah MadaUniversitas Gadjah Mada Banana (Musa paradiasiaca var. sapientum) is the world's most popular fruit-bearing crop, with rising consumption and waste. This study aimed to measure the metabolite compound and evaluate the gastroprotective properties of a banana peel-purified methanol extract. Animals test used in this study were divided into six groups: Group One received NaCMC 0.5%, Group Two received sucralfate, Group Three received aspirin 1000 mg/kg body weight, and groups four, five, and six received PBP at doses of 200 mg/kg body weight, 400 mg/kg body weight, and 600 mg/kg body weight, respectively, for seven days. Except for group 1, all groups were induced with aspirin at 1000 mg/kg body weight on the eighth day. The result of this study exhibited banana peel containing total phenolic, flavonoid, and tannin compounds with concentrations of 33.45 mg GAE/g, 19.92 mg QE/g, and 0.16 %, respectively. The results showed that pure extract of Musa paradiasiaca var. sapientum fruit peel can reduce the incidence of gastric ulcers by decreasing the ulcer index (p<0.05).. The results suggested that Musa paradisiaca var. sapientum peel has a gastroprotective effect against aspirin-induced gastric ulceration. https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/27639Musa paradisiaca var. sapientum peelGastric ulcerPurified extract |
| spellingShingle | Jastria Pusmarani Risky Juliansyah Putri Citra Dewi Difa Fitriani Setyo Purwono Zullies Ikawati Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats Pharmaciana Musa paradisiaca var. sapientum peel Gastric ulcer Purified extract |
| title | Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats |
| title_full | Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats |
| title_fullStr | Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats |
| title_full_unstemmed | Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats |
| title_short | Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats |
| title_sort | gastroprotective activity of banana peel musa paradisiaca var sapientum methanol extract purified on aspirin induced gastric ulceration in rats |
| topic | Musa paradisiaca var. sapientum peel Gastric ulcer Purified extract |
| url | https://journal.uad.ac.id/index.php/PHARMACIANA/article/view/27639 |
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