Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT
Abstract Hybrid depth electrodes are increasingly being used for epilepsy monitoring and human neurophysiology research. Microwires extending from the tip of the Behnke‐Fried (BF) electrode into (sub)cortical areas allow to isolate single neurons and perform microstimulation. Conventional CT or MRI...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Epilepsia Open |
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| Online Access: | https://doi.org/10.1002/epi4.13080 |
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| author | Steven Smeijers Walter Coudyzer Elina Keirse Vasiliki Bougou Thomas Decramer Tom Theys |
| author_facet | Steven Smeijers Walter Coudyzer Elina Keirse Vasiliki Bougou Thomas Decramer Tom Theys |
| author_sort | Steven Smeijers |
| collection | DOAJ |
| description | Abstract Hybrid depth electrodes are increasingly being used for epilepsy monitoring and human neurophysiology research. Microwires extending from the tip of the Behnke‐Fried (BF) electrode into (sub)cortical areas allow to isolate single neurons and perform microstimulation. Conventional CT or MRI visualize the entire microwire bundle as an artifact extending from the BF electrode tip with low resolution, without proper identification of individual microwires. We illustrate the first direct visualization method of individual microwires using high‐resolution photon‐counting CT (PCCT). Coregistration of the PCCT scan with a preoperative MRI can visualize individual wires directly in cortex, which is an advantage as it provides feedback on the accuracy of the implantation method and can guide future implantations. This PCCT technique allows for accurately depicting individual microwires which could be relevant for neuroscientific research through improved visualization and implantation of specific cortical and subcortical brain areas. Plain Language Summary Researchers are using hybrid depth electrodes to study epilepsy and brain activity. These electrodes, called Behnke‐Fried (BF) electrodes, have microwires at the tip that can record single neurons and stimulate brain areas. Regular CT or MRI scans do not show the individual microwires clearly. The authors use a new high‐resolution photon‐counting CT (PCCT) technique, which can show each individual microwire in the brain. By combining PCCT with MRI, the authors can precisely see where the microwires are located. This could improve future implantation surgeries and brain research. |
| format | Article |
| id | doaj-art-8a12af32f91a481d9f8696c49976d69b |
| institution | Kabale University |
| issn | 2470-9239 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj-art-8a12af32f91a481d9f8696c49976d69b2024-12-11T17:10:11ZengWileyEpilepsia Open2470-92392024-12-01962518252110.1002/epi4.13080Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CTSteven Smeijers0Walter Coudyzer1Elina Keirse2Vasiliki Bougou3Thomas Decramer4Tom Theys5Department of Neurosurgery UZ Leuven Leuven BelgiumDepartment of Radiology UZ Leuven Leuven BelgiumResearch Group Experimental Neurosurgery and Neuroanatomy KU Leuven Leuven BelgiumResearch Group Experimental Neurosurgery and Neuroanatomy KU Leuven Leuven BelgiumDepartment of Neurosurgery UZ Leuven Leuven BelgiumDepartment of Neurosurgery UZ Leuven Leuven BelgiumAbstract Hybrid depth electrodes are increasingly being used for epilepsy monitoring and human neurophysiology research. Microwires extending from the tip of the Behnke‐Fried (BF) electrode into (sub)cortical areas allow to isolate single neurons and perform microstimulation. Conventional CT or MRI visualize the entire microwire bundle as an artifact extending from the BF electrode tip with low resolution, without proper identification of individual microwires. We illustrate the first direct visualization method of individual microwires using high‐resolution photon‐counting CT (PCCT). Coregistration of the PCCT scan with a preoperative MRI can visualize individual wires directly in cortex, which is an advantage as it provides feedback on the accuracy of the implantation method and can guide future implantations. This PCCT technique allows for accurately depicting individual microwires which could be relevant for neuroscientific research through improved visualization and implantation of specific cortical and subcortical brain areas. Plain Language Summary Researchers are using hybrid depth electrodes to study epilepsy and brain activity. These electrodes, called Behnke‐Fried (BF) electrodes, have microwires at the tip that can record single neurons and stimulate brain areas. Regular CT or MRI scans do not show the individual microwires clearly. The authors use a new high‐resolution photon‐counting CT (PCCT) technique, which can show each individual microwire in the brain. By combining PCCT with MRI, the authors can precisely see where the microwires are located. This could improve future implantation surgeries and brain research.https://doi.org/10.1002/epi4.13080Behnke‐Fried electrodeepilepsyhybrid depth electrodesmicroelectrodesphoton‐counting CT (PCCT)visualization |
| spellingShingle | Steven Smeijers Walter Coudyzer Elina Keirse Vasiliki Bougou Thomas Decramer Tom Theys Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT Epilepsia Open Behnke‐Fried electrode epilepsy hybrid depth electrodes microelectrodes photon‐counting CT (PCCT) visualization |
| title | Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT |
| title_full | Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT |
| title_fullStr | Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT |
| title_full_unstemmed | Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT |
| title_short | Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT |
| title_sort | direct visualization of microwires in hybrid depth electrodes using high resolution photon counting ct |
| topic | Behnke‐Fried electrode epilepsy hybrid depth electrodes microelectrodes photon‐counting CT (PCCT) visualization |
| url | https://doi.org/10.1002/epi4.13080 |
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