An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells.

An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells.

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Radiotherapy is a mainstay of treatment for head and neck squamous cell carcinoma (HNSCC), either definitive or adjuvant to surgery. Biological factors known to affect radiation response are hypoxia and DNA repair capacity, but several lines of evidence indicate that other genes and pathways in the...

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Main Authors: Reinout H de Roest, Marijke Buijze, Myrthe Veth, Klaas de Lint, Govind Pai, Martin A Rooimans, Rob M F Wolthuis, Arjen Brink, Jos B Poell, Ruud H Brakenhoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0329731
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