Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders
Toxoplasma gondii (T. gondii) is a protozoan parasite that affects about one-third of the world's human population, frequently creating a dormant presence in the brain. Recent studies have placed growing emphasis on the possible consequences of T. gondii infection concerning brain cancer and ne...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zabansaraye Parsian Novin Mehr Institute
2024-12-01
|
| Series: | Journal of Current Oncology and Medical Sciences |
| Subjects: | |
| Online Access: | https://submission.journalofcoms.com/index.php/JCOMS/article/view/280 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527838643060736 |
|---|---|
| author | Peyman Rabiei Mohammad Esmaeilpour-Bandboni |
| author_facet | Peyman Rabiei Mohammad Esmaeilpour-Bandboni |
| author_sort | Peyman Rabiei |
| collection | DOAJ |
| description | Toxoplasma gondii (T. gondii) is a protozoan parasite that affects about one-third of the world's human population, frequently creating a dormant presence in the brain. Recent studies have placed growing emphasis on the possible consequences of T. gondii infection concerning brain cancer and neuropsychiatric conditions, such as schizophrenia, bipolar disorder, and depression. This review consolidates recent discoveries regarding how T. gondii could affect neurological well-being, especially its capacity to modify neurotransmitter pathways, adjust immune reactions, and provoke neuroinflammation. We examine the epidemiological links between T. gondii seropositivity and different psychiatric disorders, highlighting the necessity for additional research into the causal mechanisms connecting this parasite to brain pathology. Moreover, we investigate the possibility of T. gondii as a co-factor in developing brain tumors, emphasizing its function in immune evasion and modulation of the tumor microenvironment. Grasping these connections is essential for creating focused therapeutic approaches and public health measures designed to reduce the impact of T. gondii infection on mental health and neuro-oncology.
|
| format | Article |
| id | doaj-art-8a02c0bb802448fca623b929388dcae1 |
| institution | Kabale University |
| issn | 2783-3127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj-art-8a02c0bb802448fca623b929388dcae12025-01-15T06:50:14ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272024-12-014410231030Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disordersPeyman Rabiei0Mohammad Esmaeilpour-Bandboni1Department of Veterinary Medicine, Babol-Branch, Islamic Azad University, Babol, IranDepartment of Nursing, Zeynab (P.B.U.H) School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, IranToxoplasma gondii (T. gondii) is a protozoan parasite that affects about one-third of the world's human population, frequently creating a dormant presence in the brain. Recent studies have placed growing emphasis on the possible consequences of T. gondii infection concerning brain cancer and neuropsychiatric conditions, such as schizophrenia, bipolar disorder, and depression. This review consolidates recent discoveries regarding how T. gondii could affect neurological well-being, especially its capacity to modify neurotransmitter pathways, adjust immune reactions, and provoke neuroinflammation. We examine the epidemiological links between T. gondii seropositivity and different psychiatric disorders, highlighting the necessity for additional research into the causal mechanisms connecting this parasite to brain pathology. Moreover, we investigate the possibility of T. gondii as a co-factor in developing brain tumors, emphasizing its function in immune evasion and modulation of the tumor microenvironment. Grasping these connections is essential for creating focused therapeutic approaches and public health measures designed to reduce the impact of T. gondii infection on mental health and neuro-oncology. https://submission.journalofcoms.com/index.php/JCOMS/article/view/280toxoplasma gondiibrain cancerneuropsychiatric disordersneurotransmitter modulationneuroinflammation |
| spellingShingle | Peyman Rabiei Mohammad Esmaeilpour-Bandboni Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders Journal of Current Oncology and Medical Sciences toxoplasma gondii brain cancer neuropsychiatric disorders neurotransmitter modulation neuroinflammation |
| title | Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders |
| title_full | Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders |
| title_fullStr | Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders |
| title_full_unstemmed | Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders |
| title_short | Parasite in the brain: the role of Toxoplasma gondii in brain cancer and neuropsychiatric disorders |
| title_sort | parasite in the brain the role of toxoplasma gondii in brain cancer and neuropsychiatric disorders |
| topic | toxoplasma gondii brain cancer neuropsychiatric disorders neurotransmitter modulation neuroinflammation |
| url | https://submission.journalofcoms.com/index.php/JCOMS/article/view/280 |
| work_keys_str_mv | AT peymanrabiei parasiteinthebraintheroleoftoxoplasmagondiiinbraincancerandneuropsychiatricdisorders AT mohammadesmaeilpourbandboni parasiteinthebraintheroleoftoxoplasmagondiiinbraincancerandneuropsychiatricdisorders |