Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction

Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction

Abstract Background The role of one-carbon metabolism and related B-vitamins in cognitive function in ageing is well-documented, particularly for folate and vitamin B12, with vitamin B6 and riboflavin receiving much less attention. ApoE is a well-established genetic risk factor for Alzheimer’s disea...

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Main Authors: Shane Gordon, Leane Hoey, Helene McNulty, Jordan Keenan, Faith Pangilinan, Lawrence C. Brody, Mary Ward, J. J. Strain, Liadhan McAnena, Adrian McCann, Anne M. Molloy, Conal Cunningham, Kevin McCarroll, Catherine F. Hughes
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Cognitive function
Folate
Vitamin B12
Vitamin B6
Riboflavin
Homocysteine
Online Access:https://doi.org/10.1186/s12916-025-04276-8
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https://doi.org/10.1186/s12916-025-04276-8

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