Periodontal bacteria influence systemic diseases through the gut microbiota
Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to estab...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1478362/full |
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| author | Mengying Xi Qijun Ruan Sulan Zhong Jiatong Li Weijuan Qi Congman Xie Xiaoyan Wang Nuerbiya Abuduxiku Jia Ni |
| author_facet | Mengying Xi Qijun Ruan Sulan Zhong Jiatong Li Weijuan Qi Congman Xie Xiaoyan Wang Nuerbiya Abuduxiku Jia Ni |
| author_sort | Mengying Xi |
| collection | DOAJ |
| description | Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut. This paper provides evidence for the role of periodontal bacteria in systemic diseases via the oral-gut axis and the far-reaching implications of maintaining periodontal health in reducing the risk of many intestinal and parenteral diseases. This may provide insight into the underlying pathogenesis of many systemic diseases and the search for new preventive and therapeutic strategies. |
| format | Article |
| id | doaj-art-89ec68235b184a23a52dca87d7b718ec |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-89ec68235b184a23a52dca87d7b718ec2024-11-15T06:13:13ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-11-011410.3389/fcimb.2024.14783621478362Periodontal bacteria influence systemic diseases through the gut microbiotaMengying Xi0Qijun Ruan1Sulan Zhong2Jiatong Li3Weijuan Qi4Congman Xie5Xiaoyan Wang6Nuerbiya Abuduxiku7Jia Ni8Department of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaDepartment of Periodontics, Shenzhen Longgang Otolaryngology hospital, Shenzhen, ChinaDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaDepartment of Orthodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaDepartment of Periodontics, Shenzhen Longgang Otolaryngology hospital, Shenzhen, ChinaDepartment of Stomatology, The First People’s Hospital of Kashi, Kashi, ChinaDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, ChinaMany systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut. This paper provides evidence for the role of periodontal bacteria in systemic diseases via the oral-gut axis and the far-reaching implications of maintaining periodontal health in reducing the risk of many intestinal and parenteral diseases. This may provide insight into the underlying pathogenesis of many systemic diseases and the search for new preventive and therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1478362/fullperiodontal bacteriaoral dysbiosisgut dysbiosisoral-gut axissystemic diseasesfecal microbiota transplantation |
| spellingShingle | Mengying Xi Qijun Ruan Sulan Zhong Jiatong Li Weijuan Qi Congman Xie Xiaoyan Wang Nuerbiya Abuduxiku Jia Ni Periodontal bacteria influence systemic diseases through the gut microbiota Frontiers in Cellular and Infection Microbiology periodontal bacteria oral dysbiosis gut dysbiosis oral-gut axis systemic diseases fecal microbiota transplantation |
| title | Periodontal bacteria influence systemic diseases through the gut microbiota |
| title_full | Periodontal bacteria influence systemic diseases through the gut microbiota |
| title_fullStr | Periodontal bacteria influence systemic diseases through the gut microbiota |
| title_full_unstemmed | Periodontal bacteria influence systemic diseases through the gut microbiota |
| title_short | Periodontal bacteria influence systemic diseases through the gut microbiota |
| title_sort | periodontal bacteria influence systemic diseases through the gut microbiota |
| topic | periodontal bacteria oral dysbiosis gut dysbiosis oral-gut axis systemic diseases fecal microbiota transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1478362/full |
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