Berberine Mitigates Sepsis-Associated Acute Kidney Injury in Aged Rats by Preserving Mitochondrial Integrity and Inhibiting TLR4/NF-κB and NLRP3 Inflammasome Activations

Berberine Mitigates Sepsis-Associated Acute Kidney Injury in Aged Rats by Preserving Mitochondrial Integrity and Inhibiting TLR4/NF-κB and NLRP3 Inflammasome Activations

Sepsis-associated acute kidney injury (SA-AKI) presents a severe challenge in the elderly due to increasing incidence, high mortality, and the lack of specific effective treatments. Exploring novel and secure preventive and/or therapeutic approaches is critical and urgent. Berberine (BBR), an isoqui...

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Bibliographic Details
Main Authors: Ruedeemars Yubolphan, Anongporn Kobroob, Apisek Kongkaew, Natthakarn Chiranthanut, Natthanicha Jinadang, Orawan Wongmekiat
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antioxidants
Subjects:
acute kidney injury
sepsis
aging
berberine
oxidative stress
inflammation
Online Access:https://www.mdpi.com/2076-3921/13/11/1398
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