Leveraging the microbiome to combat antibiotic resistant gynecological infections
Abstract The vaginal resistome can be considered a collection of the resistant determinants in the vaginal microbiome. Here we review the vaginal resistome including the microbes and resistant genes harbored in common gynecological infections, vaginal microbes that participate in horizontal gene tra...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | npj Antimicrobials and Resistance |
| Online Access: | https://doi.org/10.1038/s44259-025-00106-2 |
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| _version_ | 1849311037283631104 |
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| author | Tanya Kumar Aryak Rekhi Yumie Lee Julielam Tran Arlene Grace D. Nagtalon Sidhant Rohatgi Erika L. Cyphert |
| author_facet | Tanya Kumar Aryak Rekhi Yumie Lee Julielam Tran Arlene Grace D. Nagtalon Sidhant Rohatgi Erika L. Cyphert |
| author_sort | Tanya Kumar |
| collection | DOAJ |
| description | Abstract The vaginal resistome can be considered a collection of the resistant determinants in the vaginal microbiome. Here we review the vaginal resistome including the microbes and resistant genes harbored in common gynecological infections, vaginal microbes that participate in horizontal gene transfer, host factors that contribute to the resistome, and common therapies. Finally, we provide perspective on technologies that can be leveraged to study the vaginal resistome and remaining challenges. |
| format | Article |
| id | doaj-art-8985480b17d0495d9969b7b7aaf552b1 |
| institution | Kabale University |
| issn | 2731-8745 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Antimicrobials and Resistance |
| spelling | doaj-art-8985480b17d0495d9969b7b7aaf552b12025-08-20T03:53:32ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-04-013111310.1038/s44259-025-00106-2Leveraging the microbiome to combat antibiotic resistant gynecological infectionsTanya Kumar0Aryak Rekhi1Yumie Lee2Julielam Tran3Arlene Grace D. Nagtalon4Sidhant Rohatgi5Erika L. Cyphert6University of California San Diego, Shu Chien-Gene Lay Department of BioengineeringUniversity of California San Diego, Shu Chien-Gene Lay Department of BioengineeringUniversity of California San Diego, Shu Chien-Gene Lay Department of BioengineeringUniversity of California San Diego, Shu Chien-Gene Lay Department of BioengineeringUniversity of California San Diego, Shu Chien-Gene Lay Department of BioengineeringUniversity of California San Diego, Shu Chien-Gene Lay Department of BioengineeringUniversity of California San Diego, Shu Chien-Gene Lay Department of BioengineeringAbstract The vaginal resistome can be considered a collection of the resistant determinants in the vaginal microbiome. Here we review the vaginal resistome including the microbes and resistant genes harbored in common gynecological infections, vaginal microbes that participate in horizontal gene transfer, host factors that contribute to the resistome, and common therapies. Finally, we provide perspective on technologies that can be leveraged to study the vaginal resistome and remaining challenges.https://doi.org/10.1038/s44259-025-00106-2 |
| spellingShingle | Tanya Kumar Aryak Rekhi Yumie Lee Julielam Tran Arlene Grace D. Nagtalon Sidhant Rohatgi Erika L. Cyphert Leveraging the microbiome to combat antibiotic resistant gynecological infections npj Antimicrobials and Resistance |
| title | Leveraging the microbiome to combat antibiotic resistant gynecological infections |
| title_full | Leveraging the microbiome to combat antibiotic resistant gynecological infections |
| title_fullStr | Leveraging the microbiome to combat antibiotic resistant gynecological infections |
| title_full_unstemmed | Leveraging the microbiome to combat antibiotic resistant gynecological infections |
| title_short | Leveraging the microbiome to combat antibiotic resistant gynecological infections |
| title_sort | leveraging the microbiome to combat antibiotic resistant gynecological infections |
| url | https://doi.org/10.1038/s44259-025-00106-2 |
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