Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis

Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis

IntroductionSepsis is a risk factor for acute kidney injury (AKI) in neonates, for which no effective treatment exists. The phosphodiesterase inhibitor pentoxifylline (PTX) has demonstrated renal protection from ischemia and inflammation in adult rodents. We hypothesized that addition of PTX to anti...

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Bibliographic Details
Main Authors:	Esther M. Speer, Atilade A. Adedeji, Joyce Lin, Alexandra Khorasanchi, Asma Rasheed, Maya Bhat, Kelly Mackenzie, Randolph Hennigar, Kimberly J. Reidy, Robert P. Woroniecki
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Cellular and Infection Microbiology
Subjects:	neonatal sepsis acute kidney injury (AKI) inflammatory response kidney injury markers anti-inflammatory agents pentoxifylline
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2024.1507914/full
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