Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules
In recent years, increasing evidence has highlighted the critical role of myeloid cells, specifically those that present antigen (APCs) in health and disease. These shape the progression and development of neurodegenerative disorders, where considerable interplay between the immune system and neuron...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1488382/full |
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| author | Reham Afify Katherine Lipsius Season J. Wyatt-Johnson Randy R. Brutkiewicz |
| author_facet | Reham Afify Katherine Lipsius Season J. Wyatt-Johnson Randy R. Brutkiewicz |
| author_sort | Reham Afify |
| collection | DOAJ |
| description | In recent years, increasing evidence has highlighted the critical role of myeloid cells, specifically those that present antigen (APCs) in health and disease. These shape the progression and development of neurodegenerative disorders, where considerable interplay between the immune system and neurons influences the course of disease pathogenesis. Antigen-presenting myeloid cells display different classes of major histocompatibility complex (MHC) and MHC-like proteins on their surface for presenting various types of antigens to a wide variety of T cells. While most studies focus on the role of myeloid MHC class I and II molecules in health and disease, there is still much that remains unknown about non-polymorphic MHC-like molecules such as CD1d and MR1. Thus, in this review, we will summarize the recent findings regarding the contributions of both classical and non-classical MHC molecules, particularly on myeloid microglial APCs, in neurodegenerative diseases. This will offer a better understanding of altered mechanisms that may pave the way for the development of novel therapeutic strategies targeting immune cell-MHC interactions, to mitigate neurodegeneration and its associated pathology. |
| format | Article |
| id | doaj-art-893f8e0e48264216a8ecf5e41e8e5f7b |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-893f8e0e48264216a8ecf5e41e8e5f7b2024-12-09T06:28:31ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-12-011810.3389/fnins.2024.14883821488382Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC moleculesReham AfifyKatherine LipsiusSeason J. Wyatt-JohnsonRandy R. BrutkiewiczIn recent years, increasing evidence has highlighted the critical role of myeloid cells, specifically those that present antigen (APCs) in health and disease. These shape the progression and development of neurodegenerative disorders, where considerable interplay between the immune system and neurons influences the course of disease pathogenesis. Antigen-presenting myeloid cells display different classes of major histocompatibility complex (MHC) and MHC-like proteins on their surface for presenting various types of antigens to a wide variety of T cells. While most studies focus on the role of myeloid MHC class I and II molecules in health and disease, there is still much that remains unknown about non-polymorphic MHC-like molecules such as CD1d and MR1. Thus, in this review, we will summarize the recent findings regarding the contributions of both classical and non-classical MHC molecules, particularly on myeloid microglial APCs, in neurodegenerative diseases. This will offer a better understanding of altered mechanisms that may pave the way for the development of novel therapeutic strategies targeting immune cell-MHC interactions, to mitigate neurodegeneration and its associated pathology.https://www.frontiersin.org/articles/10.3389/fnins.2024.1488382/fullmyeloid cellsmicrogliaMHCMR1CD1dneurodegenerative diseases |
| spellingShingle | Reham Afify Katherine Lipsius Season J. Wyatt-Johnson Randy R. Brutkiewicz Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules Frontiers in Neuroscience myeloid cells microglia MHC MR1 CD1d neurodegenerative diseases |
| title | Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules |
| title_full | Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules |
| title_fullStr | Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules |
| title_full_unstemmed | Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules |
| title_short | Myeloid antigen-presenting cells in neurodegenerative diseases: a focus on classical and non-classical MHC molecules |
| title_sort | myeloid antigen presenting cells in neurodegenerative diseases a focus on classical and non classical mhc molecules |
| topic | myeloid cells microglia MHC MR1 CD1d neurodegenerative diseases |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1488382/full |
| work_keys_str_mv | AT rehamafify myeloidantigenpresentingcellsinneurodegenerativediseasesafocusonclassicalandnonclassicalmhcmolecules AT katherinelipsius myeloidantigenpresentingcellsinneurodegenerativediseasesafocusonclassicalandnonclassicalmhcmolecules AT seasonjwyattjohnson myeloidantigenpresentingcellsinneurodegenerativediseasesafocusonclassicalandnonclassicalmhcmolecules AT randyrbrutkiewicz myeloidantigenpresentingcellsinneurodegenerativediseasesafocusonclassicalandnonclassicalmhcmolecules |