The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers
Primary and metastatic tumors of the nervous system represent a diverse group of neoplasms, each characterized by distinct biological features, prognostic outcomes, and therapeutic approaches. Due to their molecular complexity and heterogeneity, nervous system cancers (NSCs) pose significant clinica...
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2024-12-01
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| author | Estera Okoń Wirginia Kukula-Koch Agata Jarząb Katarzyna Gaweł-Bęben Ewelina Bator Magdalena Michalak-Tomczyk Jacek Jachuła Beata Antosiewicz-Klimczak Adrian Odrzywolski Wojciech Koch Anna Wawruszak |
| author_facet | Estera Okoń Wirginia Kukula-Koch Agata Jarząb Katarzyna Gaweł-Bęben Ewelina Bator Magdalena Michalak-Tomczyk Jacek Jachuła Beata Antosiewicz-Klimczak Adrian Odrzywolski Wojciech Koch Anna Wawruszak |
| author_sort | Estera Okoń |
| collection | DOAJ |
| description | Primary and metastatic tumors of the nervous system represent a diverse group of neoplasms, each characterized by distinct biological features, prognostic outcomes, and therapeutic approaches. Due to their molecular complexity and heterogeneity, nervous system cancers (NSCs) pose significant clinical challenges. For decades, plants and their natural products with established anticancer properties have played a pivotal role in the treatment of various medical conditions, including cancers. Anthraquinone derivatives, a class of tricyclic secondary metabolites, are found in several botanical families, such as <i>Fabaceae</i>, <i>Polygonaceae</i>, <i>Rhamnaceae</i>, and <i>Rubiaceae</i>. In a comprehensive review, recent advancements in the anticancer properties of 1,8-dihydroanthraquinone derivatives—such as emodin, aloe-emodin, hypericin, chrysophanol, rhein, and physcion—were analyzed. These compounds have been studied extensively, both used individually and in combination with other chemotherapeutic agents, using in vitro and in vivo models of nervous system tumors. It was demonstrated that 1,8-dihydroanthraquinone derivatives induce apoptosis and necrosis in cancerous cells, intercalate into DNA, disrupting transcription and replication in rapidly dividing cells, and alter ROS levels, leading to oxidative stress that damages tumor cells. Additionally, they can influence signaling pathways involved in oncogenesis, such as MAPK, PI3K/Akt, or others crucial for the survival and the proliferation of NSC cells. The exploration of 1,8-dihydroanthraquinone derivatives aims to develop novel therapies that could overcome resistance and improve cancer patients’ outcomes. |
| format | Article |
| id | doaj-art-8938cbf5040a452ea9cc9184fe0d812b |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-8938cbf5040a452ea9cc9184fe0d812b2024-12-27T14:42:52ZengMDPI AGMolecules1420-30492024-12-012924598910.3390/molecules29245989The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System CancersEstera Okoń0Wirginia Kukula-Koch1Agata Jarząb2Katarzyna Gaweł-Bęben3Ewelina Bator4Magdalena Michalak-Tomczyk5Jacek Jachuła6Beata Antosiewicz-Klimczak7Adrian Odrzywolski8Wojciech Koch9Anna Wawruszak10Department of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, PolandDepartment of Pharmacognosy with Medical Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, PolandDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego, 35-225 Rzeszów, PolandInterdisciplinary Center for Preclinical and Clinical Research, Rzeszow University, 2a Werynia, 36-100 Kolbuszowa, PolandDepartment of Physiology and Toxicology, The John Paul II Catholic University of Lublin, 1I Konstantynów Str., 20-708 Lublin, PolandDepartment of Botany, Mycology and Ecology, Institute of Biological Sciences, Maria Curie-Skłodowska University, 19 Akademicka Str., 20-033 Lublin, PolandDepartment of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego, 35-225 Rzeszów, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, PolandDepartment of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, PolandDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, PolandPrimary and metastatic tumors of the nervous system represent a diverse group of neoplasms, each characterized by distinct biological features, prognostic outcomes, and therapeutic approaches. Due to their molecular complexity and heterogeneity, nervous system cancers (NSCs) pose significant clinical challenges. For decades, plants and their natural products with established anticancer properties have played a pivotal role in the treatment of various medical conditions, including cancers. Anthraquinone derivatives, a class of tricyclic secondary metabolites, are found in several botanical families, such as <i>Fabaceae</i>, <i>Polygonaceae</i>, <i>Rhamnaceae</i>, and <i>Rubiaceae</i>. In a comprehensive review, recent advancements in the anticancer properties of 1,8-dihydroanthraquinone derivatives—such as emodin, aloe-emodin, hypericin, chrysophanol, rhein, and physcion—were analyzed. These compounds have been studied extensively, both used individually and in combination with other chemotherapeutic agents, using in vitro and in vivo models of nervous system tumors. It was demonstrated that 1,8-dihydroanthraquinone derivatives induce apoptosis and necrosis in cancerous cells, intercalate into DNA, disrupting transcription and replication in rapidly dividing cells, and alter ROS levels, leading to oxidative stress that damages tumor cells. Additionally, they can influence signaling pathways involved in oncogenesis, such as MAPK, PI3K/Akt, or others crucial for the survival and the proliferation of NSC cells. The exploration of 1,8-dihydroanthraquinone derivatives aims to develop novel therapies that could overcome resistance and improve cancer patients’ outcomes.https://www.mdpi.com/1420-3049/29/24/5989nervous system cancersnatural productsbiological activity1,8-dihydroanthraquinone derivativesemodinaloe-emodin |
| spellingShingle | Estera Okoń Wirginia Kukula-Koch Agata Jarząb Katarzyna Gaweł-Bęben Ewelina Bator Magdalena Michalak-Tomczyk Jacek Jachuła Beata Antosiewicz-Klimczak Adrian Odrzywolski Wojciech Koch Anna Wawruszak The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers Molecules nervous system cancers natural products biological activity 1,8-dihydroanthraquinone derivatives emodin aloe-emodin |
| title | The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers |
| title_full | The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers |
| title_fullStr | The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers |
| title_full_unstemmed | The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers |
| title_short | The Activity of 1,8-Dihydroanthraquinone Derivatives in Nervous System Cancers |
| title_sort | activity of 1 8 dihydroanthraquinone derivatives in nervous system cancers |
| topic | nervous system cancers natural products biological activity 1,8-dihydroanthraquinone derivatives emodin aloe-emodin |
| url | https://www.mdpi.com/1420-3049/29/24/5989 |
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