Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism

Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism

Abstract Therapies against hematological malignancies using chimeric antigen receptors (CAR)‐T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer‐specific solid tumor...

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Bibliographic Details
Main Authors: Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:MedComm
Subjects:
adoptive T cell therapy
cancer
CAR‐T cell
magnetic cell targeting
pyroptosis
superparamagnetic iron oxide nanoparticles (SPIONs)
Online Access:https://doi.org/10.1002/mco2.70039
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