A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

Abstract Eilat (EILV)/chikungunya virus (CHIKV), an insect-based chimeric alphavirus was previously reported to protect mice months after a single dose vaccination. The underlying mechanisms of host protection are not clearly defined. Here, we assessed the capacity of EILV/CHIKV to induce quick and...

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Bibliographic Details
Main Authors: Awadalkareem Adam, Courtney Woolsey, Hannah Lu, Kenneth Plante, Shannon M. Wallace, Leslie Rodriguez, Divya P. Shinde, Yingjun Cui, Alexander W. E. Franz, Saravanan Thangamani, Jason E. Comer, Scott C. Weaver, Tian Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01047-z
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