Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis
Introduction. Diabetic population has a higher risk of colorectal cancer (CRC) incidence and mortality than nondiabetics. The role of metformin in CRC prognosis is still controversial. The meta-analysis aims to investigate whether metformin improves the survival of diabetic CRC patients. Methods. Pu...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5063239 |
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| _version_ | 1841524876582584320 |
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| author | Fanqiang Meng Li Song Wenyue Wang |
| author_facet | Fanqiang Meng Li Song Wenyue Wang |
| author_sort | Fanqiang Meng |
| collection | DOAJ |
| description | Introduction. Diabetic population has a higher risk of colorectal cancer (CRC) incidence and mortality than nondiabetics. The role of metformin in CRC prognosis is still controversial. The meta-analysis aims to investigate whether metformin improves the survival of diabetic CRC patients. Methods. PubMed, EMBASE, and Cochrane Library were searched till July 1, 2016. Cohort studies were included. All articles were evaluated by Newcastle-Ottawa Scale. Hazard Ratios (HRs) with 95% confidence intervals (CIs) for each study were calculated and pooled HRs with corresponding 95% CIs were generated using the random-effects model. Heterogeneity and publication bias were assessed. Results. We included seven cohort studies with a medium heterogeneity (I2 = 56.1% and p=0.033) in our meta-analysis. An improved overall survival (OS) for metformin users over nonusers among colorectal cancers with diabetes was noted (HR 0.75; 95% CI 0.65 to 0.87). However, metformin reveals no benefits for cancer-specific survival (HR 0.79, 95%, CI 0.58 to 1.08). Conclusions. Metformin prolongs the OS of diabetic CRC patients, but it does not affect the CRC-specific survival. Metformin may be a good choice in treating CRC patients with diabetes mellitus in clinical settings. |
| format | Article |
| id | doaj-art-88f2add548ae4e4c8ca8d71cd57efb36 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-88f2add548ae4e4c8ca8d71cd57efb362025-02-03T05:47:09ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/50632395063239Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-AnalysisFanqiang Meng0Li Song1Wenyue Wang2Department of Gastrointestinal Surgery, China-Japan Friendship Hospital, Beijing 100029, ChinaDepartment of Gastrointestinal Surgery, China-Japan Friendship Hospital, Beijing 100029, ChinaDepartment of Gastrointestinal Surgery, China-Japan Friendship Hospital, Beijing 100029, ChinaIntroduction. Diabetic population has a higher risk of colorectal cancer (CRC) incidence and mortality than nondiabetics. The role of metformin in CRC prognosis is still controversial. The meta-analysis aims to investigate whether metformin improves the survival of diabetic CRC patients. Methods. PubMed, EMBASE, and Cochrane Library were searched till July 1, 2016. Cohort studies were included. All articles were evaluated by Newcastle-Ottawa Scale. Hazard Ratios (HRs) with 95% confidence intervals (CIs) for each study were calculated and pooled HRs with corresponding 95% CIs were generated using the random-effects model. Heterogeneity and publication bias were assessed. Results. We included seven cohort studies with a medium heterogeneity (I2 = 56.1% and p=0.033) in our meta-analysis. An improved overall survival (OS) for metformin users over nonusers among colorectal cancers with diabetes was noted (HR 0.75; 95% CI 0.65 to 0.87). However, metformin reveals no benefits for cancer-specific survival (HR 0.79, 95%, CI 0.58 to 1.08). Conclusions. Metformin prolongs the OS of diabetic CRC patients, but it does not affect the CRC-specific survival. Metformin may be a good choice in treating CRC patients with diabetes mellitus in clinical settings.http://dx.doi.org/10.1155/2017/5063239 |
| spellingShingle | Fanqiang Meng Li Song Wenyue Wang Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis Journal of Diabetes Research |
| title | Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis |
| title_full | Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis |
| title_fullStr | Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis |
| title_full_unstemmed | Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis |
| title_short | Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis |
| title_sort | metformin improves overall survival of colorectal cancer patients with diabetes a meta analysis |
| url | http://dx.doi.org/10.1155/2017/5063239 |
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