Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis
Introduction: Aedes-borne arboviral infections, both imported and autochthonous, are reported in Europe. We evaluated the landscape of these infections in Europe over 23 years and attempted to pre-empt the trajectory of impact of these infections in the climatic context of Aedes mosquito expansion i...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Travel Medicine and Infectious Disease |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1477893925000055 |
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| author | Nadja Hedrich Maria Bekker-Nielsen Dunbar Martin P. Grobusch Patricia Schlagenhauf |
| author_facet | Nadja Hedrich Maria Bekker-Nielsen Dunbar Martin P. Grobusch Patricia Schlagenhauf |
| author_sort | Nadja Hedrich |
| collection | DOAJ |
| description | Introduction: Aedes-borne arboviral infections, both imported and autochthonous, are reported in Europe. We evaluated the landscape of these infections in Europe over 23 years and attempted to pre-empt the trajectory of impact of these infections in the climatic context of Aedes mosquito expansion in Europe. Methods: This systematic review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42023360259). PubMed, Embase, Web of Science, IEEE Xplore, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and the European Centre for Disease Prevention and Control (ECDC) websites were searched for publications reporting on cases of Aedes-borne infection in Europe between January 1st, 2000, and December 31st, 2023. Results: Some 353 papers were included, covering 59,589 cases of infection in Europe by seven arboviruses: dengue, Zika, chikungunya, yellow fever, Mayaro, Ross River, and Rift Valley. Most cases (55,924) were travel related, while 5 % were autochthonous. There were 59 cases of non-vector-borne transmission, primarily Zika-related sexual transmissions. Nineteen deaths were reported, of which three were associated with chikungunya virus infection, 12 with dengue, and four with yellow fever. Notable sequelae included persistent arthralgia from chikungunya and neurological effects in Zika-infected infants. The meta-analysis of 31 studies revealed a pooled prevalence of 0.047 (95 % CI: 0.03–0.07) in symptomatic returning travelers. Conclusion: The systematic review provides a comprehensive overview of over 20 years of Aedes -borne infections in Europe, highlighting the dynamic nature of virus transmission influenced by global travel patterns, climate change, the expanding spread of Aedes populations, and evolving public health campaigns. |
| format | Article |
| id | doaj-art-88ef9903620549aa859679e7409a6c88 |
| institution | Kabale University |
| issn | 1873-0442 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Travel Medicine and Infectious Disease |
| spelling | doaj-art-88ef9903620549aa859679e7409a6c882025-01-18T05:03:46ZengElsevierTravel Medicine and Infectious Disease1873-04422025-03-0164102799Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysisNadja Hedrich0Maria Bekker-Nielsen Dunbar1Martin P. Grobusch2Patricia Schlagenhauf3University of Zürich, Epidemiology, Biostatistics and Prevention Institute, Hirschengraben 84, 8001, Zürich, Switzerland; Corresponding author. Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Hirschengraben 84, 8001, Zürich, Switzerland.nadja.hedrich@uzh.chUniversity of Zürich, Epidemiology, Biostatistics and Prevention Institute, Hirschengraben 84, 8001, Zürich, Switzerland; Centre for Research on Pandemics & Society, OsloMet – Oslo Metropolitan University, Holbergsgate 1, 0166, Oslo, NorwayCenter for Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam UMC, location University of Amsterdam, Amsterdam, NetherlandsUniversity of Zürich, Epidemiology, Biostatistics and Prevention Institute, Hirschengraben 84, 8001, Zürich, Switzerland; WHO Collaborating Centre for Travellers' Health, Department of Global and Public Health, MilMedBiol Competence Centre, Hirschengraben 84, 8001, Zürich, SwitzerlandIntroduction: Aedes-borne arboviral infections, both imported and autochthonous, are reported in Europe. We evaluated the landscape of these infections in Europe over 23 years and attempted to pre-empt the trajectory of impact of these infections in the climatic context of Aedes mosquito expansion in Europe. Methods: This systematic review was conducted in accordance with PRISMA guidelines and registered in Prospero (CRD42023360259). PubMed, Embase, Web of Science, IEEE Xplore, and Cochrane Central Register of Controlled Trials (CENTRAL) databases and the European Centre for Disease Prevention and Control (ECDC) websites were searched for publications reporting on cases of Aedes-borne infection in Europe between January 1st, 2000, and December 31st, 2023. Results: Some 353 papers were included, covering 59,589 cases of infection in Europe by seven arboviruses: dengue, Zika, chikungunya, yellow fever, Mayaro, Ross River, and Rift Valley. Most cases (55,924) were travel related, while 5 % were autochthonous. There were 59 cases of non-vector-borne transmission, primarily Zika-related sexual transmissions. Nineteen deaths were reported, of which three were associated with chikungunya virus infection, 12 with dengue, and four with yellow fever. Notable sequelae included persistent arthralgia from chikungunya and neurological effects in Zika-infected infants. The meta-analysis of 31 studies revealed a pooled prevalence of 0.047 (95 % CI: 0.03–0.07) in symptomatic returning travelers. Conclusion: The systematic review provides a comprehensive overview of over 20 years of Aedes -borne infections in Europe, highlighting the dynamic nature of virus transmission influenced by global travel patterns, climate change, the expanding spread of Aedes populations, and evolving public health campaigns.http://www.sciencedirect.com/science/article/pii/S1477893925000055 |
| spellingShingle | Nadja Hedrich Maria Bekker-Nielsen Dunbar Martin P. Grobusch Patricia Schlagenhauf Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis Travel Medicine and Infectious Disease |
| title | Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis |
| title_full | Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis |
| title_fullStr | Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis |
| title_full_unstemmed | Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis |
| title_short | Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis |
| title_sort | aedes borne arboviral human infections in europe from 2000 to 2023 a systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1477893925000055 |
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