Near-infrared organic nanoparticles (6BQ NPs) enhance the random flaps survival by modulating the HSP90/HIF-1α axis through mild photothermal therapy

Near-infrared organic nanoparticles (6BQ NPs) enhance the random flaps survival by modulating the HSP90/HIF-1α axis through mild photothermal therapy

Abstract Random flaps are primarily employed in clinical practice for wound repair; however, the ischemic necrosis following surgery remains a significant challenge. To address this issue, we developed high-performance near-infrared (NIR) photothermal agent, 6BQ, to enhance random flaps survival thr...

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Bibliographic Details
Main Authors: Feng Wu, Jin Zhang, Jiangtian Ye, Jinwu Wang, Wenhao Zheng, Hua Chen, Xiaoyu Dong, Zu-Sheng Huang, Leyi Cai, Guangheng Xiang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Near-infrared organic nanoparticles
Mild photothermal therapy
HSP90/HIF-1α axis
Angiogenesis
Ischemia–reperfusion injury
Random flaps
Online Access:https://doi.org/10.1186/s12951-025-03570-0
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