Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases
Significance: ALA-PDT effectively treats Vulvar lichen sclerosus et atrophicus (VLSA), but it requires multiple repetitions for satisfactory results. To enhance efficacy, we employed a combination of high-frequency electrocautery therapy and ALA-PDT in treating seven VLSA patients. Approach: Lesions...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006518 |
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| author | Shanshan Ou Huanli Wang Weiyu Liu Huilan Zhu Wenjun Zhang Huaping Li Huiyan Deng |
| author_facet | Shanshan Ou Huanli Wang Weiyu Liu Huilan Zhu Wenjun Zhang Huaping Li Huiyan Deng |
| author_sort | Shanshan Ou |
| collection | DOAJ |
| description | Significance: ALA-PDT effectively treats Vulvar lichen sclerosus et atrophicus (VLSA), but it requires multiple repetitions for satisfactory results. To enhance efficacy, we employed a combination of high-frequency electrocautery therapy and ALA-PDT in treating seven VLSA patients. Approach: Lesions and leukoplakia in the seven women with VLSA were removed using a high-frequency generator. PDT was administered after wound healing, and it was repeated six times. Follow-up assessments were carried out at 1, 3, and 6 months to evaluate the severity of pruritus and investigate lesion repigmentation. Results: Following the combined therapy, the disappearance of pruritus was observed in all patients, and normal color and thickness were restored to their skin. Two patients reported mild pruritus with a score of 2 one month after treatment, which persisted until the 6-month follow-up, while the remaining patients remained free from pruritus. No recurrence of skin lesions was observed in any of the patients. Conclusions: The combined therapy for the treatment of VLSA is found to be convenient, effective, and easily promotable. |
| format | Article |
| id | doaj-art-88d6f361e30746ff8d3dcd2cef1b04aa |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-88d6f361e30746ff8d3dcd2cef1b04aa2024-12-11T05:55:20ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-0145103924Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven casesShanshan Ou0Huanli Wang1Weiyu Liu2Huilan Zhu3Wenjun Zhang4Huaping Li5Huiyan Deng6Department of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, ChinaDepartment of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, ChinaDepartment of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, ChinaDepartment of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, ChinaDepartment of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, ChinaDepartment of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, ChinaDepartment of Dermatology, Guangzhou Institute of Dermatology, No.56, Hengfu Road, Guangzhou 510095, China; Corresponding author.Significance: ALA-PDT effectively treats Vulvar lichen sclerosus et atrophicus (VLSA), but it requires multiple repetitions for satisfactory results. To enhance efficacy, we employed a combination of high-frequency electrocautery therapy and ALA-PDT in treating seven VLSA patients. Approach: Lesions and leukoplakia in the seven women with VLSA were removed using a high-frequency generator. PDT was administered after wound healing, and it was repeated six times. Follow-up assessments were carried out at 1, 3, and 6 months to evaluate the severity of pruritus and investigate lesion repigmentation. Results: Following the combined therapy, the disappearance of pruritus was observed in all patients, and normal color and thickness were restored to their skin. Two patients reported mild pruritus with a score of 2 one month after treatment, which persisted until the 6-month follow-up, while the remaining patients remained free from pruritus. No recurrence of skin lesions was observed in any of the patients. Conclusions: The combined therapy for the treatment of VLSA is found to be convenient, effective, and easily promotable.http://www.sciencedirect.com/science/article/pii/S1572100023006518PDTHigh-frequency electrocautery therapyVLSAVulvar lichen sclerosus et atrophicus |
| spellingShingle | Shanshan Ou Huanli Wang Weiyu Liu Huilan Zhu Wenjun Zhang Huaping Li Huiyan Deng Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases Photodiagnosis and Photodynamic Therapy PDT High-frequency electrocautery therapy VLSA Vulvar lichen sclerosus et atrophicus |
| title | Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases |
| title_full | Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases |
| title_fullStr | Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases |
| title_full_unstemmed | Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases |
| title_short | Combination of high-frequency electrocautery therapy and ALA-PDT in hyperkeratotic vulvar lichen sclerosus: Series of seven cases |
| title_sort | combination of high frequency electrocautery therapy and ala pdt in hyperkeratotic vulvar lichen sclerosus series of seven cases |
| topic | PDT High-frequency electrocautery therapy VLSA Vulvar lichen sclerosus et atrophicus |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006518 |
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