Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy
Gastrointestinal malignant tumors exhibit a high incidence and mortality rate among all malignancies worldwide, making them a significant concern within the field of oncology. Targeted therapy for gastrointestinal tumors has become a hot topic in recent years, and its specific mechanism remains to b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1598170/full |
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| author | Yuhao Liu Yuxin Huang Qiaoying He Yuyan Shen Yaoling Wang |
| author_facet | Yuhao Liu Yuxin Huang Qiaoying He Yuyan Shen Yaoling Wang |
| author_sort | Yuhao Liu |
| collection | DOAJ |
| description | Gastrointestinal malignant tumors exhibit a high incidence and mortality rate among all malignancies worldwide, making them a significant concern within the field of oncology. Targeted therapy for gastrointestinal tumors has become a hot topic in recent years, and its specific mechanism remains to be further elucidated. Secreted factors, including cytokines, chemokines, and growth factors, as components of the tumor microenvironment, play a crucial role in the progression of gastrointestinal tumors. Interferon-gamma (IFN-γ) can activate these factors through JAK1/2 and STAT1 signaling (the IFN-γ/STAT1 pathway). This pathway is considered “a double-edged sword” and maintains a dual role in promoting or inhibiting tumor progression by activating different downstream factors. In this review, we summarize the functions, mechanisms, and key factors of the IFN-γ/STAT1 pathway that promote or inhibit gastrointestinal tumor progression and discuss therapeutic prospects for targets of the pathway. |
| format | Article |
| id | doaj-art-88cf2e2701f345f0b3295877c2064c3d |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-88cf2e2701f345f0b3295877c2064c3d2025-08-20T04:14:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15981701598170Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapyYuhao LiuYuxin HuangQiaoying HeYuyan ShenYaoling WangGastrointestinal malignant tumors exhibit a high incidence and mortality rate among all malignancies worldwide, making them a significant concern within the field of oncology. Targeted therapy for gastrointestinal tumors has become a hot topic in recent years, and its specific mechanism remains to be further elucidated. Secreted factors, including cytokines, chemokines, and growth factors, as components of the tumor microenvironment, play a crucial role in the progression of gastrointestinal tumors. Interferon-gamma (IFN-γ) can activate these factors through JAK1/2 and STAT1 signaling (the IFN-γ/STAT1 pathway). This pathway is considered “a double-edged sword” and maintains a dual role in promoting or inhibiting tumor progression by activating different downstream factors. In this review, we summarize the functions, mechanisms, and key factors of the IFN-γ/STAT1 pathway that promote or inhibit gastrointestinal tumor progression and discuss therapeutic prospects for targets of the pathway.https://www.frontiersin.org/articles/10.3389/fonc.2025.1598170/fullgastrointestinal tumorsthe IFN-γ/STAT1 pathwayimmunityinflammationtumor cell proliferation and metastasistumor cell death |
| spellingShingle | Yuhao Liu Yuxin Huang Qiaoying He Yuyan Shen Yaoling Wang Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy Frontiers in Oncology gastrointestinal tumors the IFN-γ/STAT1 pathway immunity inflammation tumor cell proliferation and metastasis tumor cell death |
| title | Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy |
| title_full | Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy |
| title_fullStr | Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy |
| title_full_unstemmed | Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy |
| title_short | Dual regulation of gastrointestinal tumor progression by the IFN-γ/STAT1 pathway and prospects for targeted therapy |
| title_sort | dual regulation of gastrointestinal tumor progression by the ifn γ stat1 pathway and prospects for targeted therapy |
| topic | gastrointestinal tumors the IFN-γ/STAT1 pathway immunity inflammation tumor cell proliferation and metastasis tumor cell death |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1598170/full |
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