Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location
Introduction: Primary extrapulmonary small cell carcinoma (EPSCC) is a rare and aggressive tumor with diverse clinical manifestations. In the realm of head and neck pathology, EPSCC most commonly presents in the larynx or oral cavity. Sinonasal small cell neuroendocrine carcinoma represents a partic...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-10-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://beta.karger.com/Article/FullText/541463 |
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| author | Anique Ahmad Jamil Abdur Rehman Sarah Arshad Anam Rafique Muhammad Shuaib Khan Arham Ihtesham Usama Shafiq Shahzaib Maqbool Javed Iqbal |
| author_facet | Anique Ahmad Jamil Abdur Rehman Sarah Arshad Anam Rafique Muhammad Shuaib Khan Arham Ihtesham Usama Shafiq Shahzaib Maqbool Javed Iqbal |
| author_sort | Anique Ahmad Jamil |
| collection | DOAJ |
| description | Introduction: Primary extrapulmonary small cell carcinoma (EPSCC) is a rare and aggressive tumor with diverse clinical manifestations. In the realm of head and neck pathology, EPSCC most commonly presents in the larynx or oral cavity. Sinonasal small cell neuroendocrine carcinoma represents a particularly infrequent and aggressive neoplasm affecting the nasal cavity and paranasal sinuses. Case Presentation: Here in, we are presenting a case of a 40-year-old nonsmoking male with left maxillary sinus EPSCC, demonstrating extensive local invasion and regional lymphadenopathy. The patient presented with nasal obstruction, ocular swelling, visual loss, and multiple neck swellings. Diagnosis was challenging, requiring a multidisciplinary approach and histopathological confirmation. Immunohistochemistry revealed positive cytokeratin AE1/AE3 and synaptophysin markers validating the diagnosis of small cell carcinoma. Conclusion: This case underscores the diagnostic complexities and highlights the importance of swift intervention and a multidisciplinary treatment approach for optimizing patient outcomes in rare and aggressive tumors like EPSCC. Early detection and prompt management are crucial in resource-limited settings to mitigate morbidity and mortality. |
| format | Article |
| id | doaj-art-88cda960cea14b4aa802c8cb074a27f4 |
| institution | Kabale University |
| issn | 1662-6575 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj-art-88cda960cea14b4aa802c8cb074a27f42024-11-14T07:28:50ZengKarger PublishersCase Reports in Oncology1662-65752024-10-011711258126510.1159/000541463541463Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare LocationAnique Ahmad Jamil0Abdur Rehman1Sarah Arshad2Anam Rafique3Muhammad Shuaib Khan4Arham Ihtesham5Usama Shafiq6Shahzaib Maqbool7Javed Iqbal8https://orcid.org/0000-0003-2627-685XDepartment of ENT, Benazir Bhutto Hospital Rawalpindi, Rawalpindi, PakistanDepartment of ENT, Benazir Bhutto Hospital Rawalpindi, Rawalpindi, PakistanGraduate of Central Park Medical College, Lahore, PakistanGraduate of Rawalpindi Medical University, Rawalpindi, PakistanDepartment of ENT, Benazir Bhutto Hospital Rawalpindi, Rawalpindi, PakistanGraduate of Rawalpindi Medical University, Rawalpindi, PakistanShifa International Hospital, Islamabad, PakistanGraduate of Rawalpindi Medical University, Rawalpindi, PakistanHamad Medical Corporation, Doha, QatarIntroduction: Primary extrapulmonary small cell carcinoma (EPSCC) is a rare and aggressive tumor with diverse clinical manifestations. In the realm of head and neck pathology, EPSCC most commonly presents in the larynx or oral cavity. Sinonasal small cell neuroendocrine carcinoma represents a particularly infrequent and aggressive neoplasm affecting the nasal cavity and paranasal sinuses. Case Presentation: Here in, we are presenting a case of a 40-year-old nonsmoking male with left maxillary sinus EPSCC, demonstrating extensive local invasion and regional lymphadenopathy. The patient presented with nasal obstruction, ocular swelling, visual loss, and multiple neck swellings. Diagnosis was challenging, requiring a multidisciplinary approach and histopathological confirmation. Immunohistochemistry revealed positive cytokeratin AE1/AE3 and synaptophysin markers validating the diagnosis of small cell carcinoma. Conclusion: This case underscores the diagnostic complexities and highlights the importance of swift intervention and a multidisciplinary treatment approach for optimizing patient outcomes in rare and aggressive tumors like EPSCC. Early detection and prompt management are crucial in resource-limited settings to mitigate morbidity and mortality.https://beta.karger.com/Article/FullText/541463small cell carcinomaextrapulmonarymaxillary sinus neoplasmsmultidisciplinary treatment approachdiagnostic challenges |
| spellingShingle | Anique Ahmad Jamil Abdur Rehman Sarah Arshad Anam Rafique Muhammad Shuaib Khan Arham Ihtesham Usama Shafiq Shahzaib Maqbool Javed Iqbal Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location Case Reports in Oncology small cell carcinoma extrapulmonary maxillary sinus neoplasms multidisciplinary treatment approach diagnostic challenges |
| title | Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location |
| title_full | Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location |
| title_fullStr | Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location |
| title_full_unstemmed | Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location |
| title_short | Primary Small Cell Carcinoma of Left Maxillary Sinus: A Case Report of Rare Tumor on Rare Location |
| title_sort | primary small cell carcinoma of left maxillary sinus a case report of rare tumor on rare location |
| topic | small cell carcinoma extrapulmonary maxillary sinus neoplasms multidisciplinary treatment approach diagnostic challenges |
| url | https://beta.karger.com/Article/FullText/541463 |
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