Case Report: Effective methotrexate removal by combined hemodialysis and polymeric resin hemoadsorption

Case Report: Effective methotrexate removal by combined hemodialysis and polymeric resin hemoadsorption

BackgroundHigh-dose methotrexate (HDMTX) is central to treating primary central nervous system lymphoma but carries a risk of acute kidney injury (AKI), which can delay methotrexate (MTX) clearance and increase toxicity. Glucarpidase is the treatment of choice for MTX toxicity, but limited access in...

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Bibliographic Details
Main Authors:	Maria Rita Dias, Carla Nicolau, Hugo Ferreira, Sérgio Chacim, Isabel Oliveira, Gonçalo de Câmara Negalha, José Mário Mariz, José Maximino Costa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Nephrology
Subjects:	methotrexate high-dose methotrexate drug toxicity acute kidney injury hemodialysis hemoadsorption
Online Access:	https://www.frontiersin.org/articles/10.3389/fneph.2025.1644079/full
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