The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas
Introduction: Determining the relationship between TP53 gene mutation and treatment outcome in high-grade gliomas patients has great significance for disease prognosis and treatment outcome monitoring. Ojectives: To determine the relationship between TP53 gene mutation rate and some characteristic...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
ECIMED
2024-05-01
|
| Series: | Revista Cubana de Medicina Militar |
| Subjects: | |
| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/35778 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841546444154077184 |
|---|---|
| author | Bac Thanh Nguyen Duc Anh Tran Hung Quang Ngo Trung Hoang Nguyen Hoa Khanh Ngo |
| author_facet | Bac Thanh Nguyen Duc Anh Tran Hung Quang Ngo Trung Hoang Nguyen Hoa Khanh Ngo |
| author_sort | Bac Thanh Nguyen |
| collection | DOAJ |
| description | Introduction: Determining the relationship between TP53 gene mutation and treatment outcome in high-grade gliomas patients has great significance for disease prognosis and treatment outcome monitoring.
Ojectives: To determine the relationship between TP53 gene mutation rate and some characteristics of treatment outcome in high-grade gliomas patients.
Methods: The study was conducted by descriptive method, on 52 high-grade gliomas patients at Vietnam National Cancer Hospital, from January 2019 to December 2020. Based on statistics of clinical symptoms, paraclinical tests and post-operative monitoring results, it was evaluated the relationship between TP53 gene mutation in study patients with response to treatment and patient's survival time.
Results: There was a relationship between TP53 gene mutation and response to treatment according to Response Evaluation Criteria In Solid Tumors (p= 0.004). Progression-free survival was higher in the group with the TP53 mutation than in the group without the TP53 mutation (χ2= 6.7; p= 0.010). The overall survival in the group with the TP53 mutation was higher than the overall survival in the group without the TP53 mutation (χ2= 2.6; p= 0.107).
Conclusion: There is a relationship between the occurrence of TP53 gene mutations with treatment response criteria and progression-free survival in patients with high-grade gliomas.
|
| format | Article |
| id | doaj-art-88c00962b9714388aea9c62418189ced |
| institution | Kabale University |
| issn | 1561-3046 |
| language | Spanish |
| publishDate | 2024-05-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista Cubana de Medicina Militar |
| spelling | doaj-art-88c00962b9714388aea9c62418189ced2025-01-10T19:01:26ZspaECIMEDRevista Cubana de Medicina Militar1561-30462024-05-01532979The relationship between TP53 Gene Mutation with treatment results in High-Grade GliomasBac Thanh Nguyen0https://orcid.org/0000-0002-8316-3088Duc Anh Tran1https://orcid.org/0000-0002-2355-2006Hung Quang Ngo2https://orcid.org/0009-0003-4703-9682Trung Hoang Nguyen3https://orcid.org/0000-0003-3527-7037Hoa Khanh Ngo4https://orcid.org/0009-0004-2733-3435Vietnam Military Medical UniversityVietnam Military Medical UniversitySaint Paul General HospitalVietnam Military Medical University108 Central Military HospitalIntroduction: Determining the relationship between TP53 gene mutation and treatment outcome in high-grade gliomas patients has great significance for disease prognosis and treatment outcome monitoring. Ojectives: To determine the relationship between TP53 gene mutation rate and some characteristics of treatment outcome in high-grade gliomas patients. Methods: The study was conducted by descriptive method, on 52 high-grade gliomas patients at Vietnam National Cancer Hospital, from January 2019 to December 2020. Based on statistics of clinical symptoms, paraclinical tests and post-operative monitoring results, it was evaluated the relationship between TP53 gene mutation in study patients with response to treatment and patient's survival time. Results: There was a relationship between TP53 gene mutation and response to treatment according to Response Evaluation Criteria In Solid Tumors (p= 0.004). Progression-free survival was higher in the group with the TP53 mutation than in the group without the TP53 mutation (χ2= 6.7; p= 0.010). The overall survival in the group with the TP53 mutation was higher than the overall survival in the group without the TP53 mutation (χ2= 2.6; p= 0.107). Conclusion: There is a relationship between the occurrence of TP53 gene mutations with treatment response criteria and progression-free survival in patients with high-grade gliomas. https://revmedmilitar.sld.cu/index.php/mil/article/view/35778genes TP53mutationgliomastreatment outcome. |
| spellingShingle | Bac Thanh Nguyen Duc Anh Tran Hung Quang Ngo Trung Hoang Nguyen Hoa Khanh Ngo The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas Revista Cubana de Medicina Militar genes TP53 mutation gliomas treatment outcome. |
| title | The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas |
| title_full | The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas |
| title_fullStr | The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas |
| title_full_unstemmed | The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas |
| title_short | The relationship between TP53 Gene Mutation with treatment results in High-Grade Gliomas |
| title_sort | relationship between tp53 gene mutation with treatment results in high grade gliomas |
| topic | genes TP53 mutation gliomas treatment outcome. |
| url | https://revmedmilitar.sld.cu/index.php/mil/article/view/35778 |
| work_keys_str_mv | AT bacthanhnguyen therelationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT ducanhtran therelationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT hungquangngo therelationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT trunghoangnguyen therelationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT hoakhanhngo therelationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT bacthanhnguyen relationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT ducanhtran relationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT hungquangngo relationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT trunghoangnguyen relationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas AT hoakhanhngo relationshipbetweentp53genemutationwithtreatmentresultsinhighgradegliomas |