Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis
Autoimmune hepatitis (AIH) is an immune-mediated liver disease that currently faces limited treatment options. In its advanced stages, AIH can progress to liver fibrosis and cirrhosis. Recent research has increasingly focused on cell-free therapies, particularly the use of mesenchymal stem cell (MSC...
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MDPI AG
2024-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/11/1353 |
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| author | Liwen Wu Longze Zhang Minglei Huang Yan Wu Sikan Jin Yaqi Zhang Xinyun Gan Ting Yu Guang Yu Jidong Zhang Xianyao Wang |
| author_facet | Liwen Wu Longze Zhang Minglei Huang Yan Wu Sikan Jin Yaqi Zhang Xinyun Gan Ting Yu Guang Yu Jidong Zhang Xianyao Wang |
| author_sort | Liwen Wu |
| collection | DOAJ |
| description | Autoimmune hepatitis (AIH) is an immune-mediated liver disease that currently faces limited treatment options. In its advanced stages, AIH can progress to liver fibrosis and cirrhosis. Recent research has increasingly focused on cell-free therapies, particularly the use of mesenchymal stem cell (MSC)-derived exosomes (Exos), which have shown promise in treating autoimmune diseases, including AIH. MSC-Exos, as microvesicles with low immunogenicity, high safety, and permeability, can deliver RNA, DNA, proteins, lipids, and various drugs for disease treatment, showing promising clinical application prospects. This review provides a comprehensive summary of the current research on MSC-Exos in the treatment of autoimmune hepatitis (AIH) and explores the underlying molecular mechanisms involved. It highlights the significant regulatory effects of MSC-Exos on immune cells and their ability to modify the microenvironment, demonstrating anti-inflammatory and anti-fibrotic properties while promoting liver regeneration. Additionally, this review also discusses potential challenges and future strategies for advancing Exo-based therapies in the treatment of AIH. |
| format | Article |
| id | doaj-art-8892c7a0deb14f0393afb57086c67636 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-8892c7a0deb14f0393afb57086c676362024-11-26T17:53:55ZengMDPI AGBiomolecules2218-273X2024-10-011411135310.3390/biom14111353Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune HepatitisLiwen Wu0Longze Zhang1Minglei Huang2Yan Wu3Sikan Jin4Yaqi Zhang5Xinyun Gan6Ting Yu7Guang Yu8Jidong Zhang9Xianyao Wang10Department of Immunology, Zunyi Medical University, Zunyi 563003, ChinaScientific Research Center, The Third Affiliated Hospital of Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaDepartment of Immunology, Zunyi Medical University, Zunyi 563003, ChinaAutoimmune hepatitis (AIH) is an immune-mediated liver disease that currently faces limited treatment options. In its advanced stages, AIH can progress to liver fibrosis and cirrhosis. Recent research has increasingly focused on cell-free therapies, particularly the use of mesenchymal stem cell (MSC)-derived exosomes (Exos), which have shown promise in treating autoimmune diseases, including AIH. MSC-Exos, as microvesicles with low immunogenicity, high safety, and permeability, can deliver RNA, DNA, proteins, lipids, and various drugs for disease treatment, showing promising clinical application prospects. This review provides a comprehensive summary of the current research on MSC-Exos in the treatment of autoimmune hepatitis (AIH) and explores the underlying molecular mechanisms involved. It highlights the significant regulatory effects of MSC-Exos on immune cells and their ability to modify the microenvironment, demonstrating anti-inflammatory and anti-fibrotic properties while promoting liver regeneration. Additionally, this review also discusses potential challenges and future strategies for advancing Exo-based therapies in the treatment of AIH.https://www.mdpi.com/2218-273X/14/11/1353mesenchymal stem cellscell-free therapyexosomesautoimmune hepatitistargeted deliveryimmunomodulation |
| spellingShingle | Liwen Wu Longze Zhang Minglei Huang Yan Wu Sikan Jin Yaqi Zhang Xinyun Gan Ting Yu Guang Yu Jidong Zhang Xianyao Wang Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis Biomolecules mesenchymal stem cells cell-free therapy exosomes autoimmune hepatitis targeted delivery immunomodulation |
| title | Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis |
| title_full | Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis |
| title_fullStr | Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis |
| title_short | Mesenchymal Stem Cell-Derived Exosomes: Emerging as a Promising Cell-Free Therapeutic Strategy for Autoimmune Hepatitis |
| title_sort | mesenchymal stem cell derived exosomes emerging as a promising cell free therapeutic strategy for autoimmune hepatitis |
| topic | mesenchymal stem cells cell-free therapy exosomes autoimmune hepatitis targeted delivery immunomodulation |
| url | https://www.mdpi.com/2218-273X/14/11/1353 |
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