Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model

Immunoproteasome inhibition reduces donor specific antibody production and cardiac allograft vasculopathy in a mouse heart transplantation model

ObjectiveCardiac Allograft Vasculopathy (CAV), a process of vascular damage accelerated by antibody-mediated rejection (AMR), is one of the leading causes of cardiac transplant failure. Proteasome inhibitors (PIs) are utilized to treat AMR, however PI-associated toxicity limits their therapeutic uti...

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Bibliographic Details
Main Authors: Allison M. Schwalb, Imran Anwar, Isabel DeLaura, Joseph M. Ladowski, Janghoon Yoon, Rafaela Belloni, Mingqing Song, Carolyn Glass, Jun Wang, Stuart Knechtle, Jean Kwun
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Transplantation
Subjects:
immunoproteasome
antibody-mediated rejection
CAV
regulatory T cells
alloantibody
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2024.1494455/full
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