The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias
Background: Adult Changes in Thought (ACT), a prospective cohort study, enrolls older adult members of Kaiser Permanente Washington. We describe an ambitious project to abstract medical records facilitating epidemiological investigation. Methods: Abstracted data include medications; laboratory resul...
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2024-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/11/1075 |
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| author | Nicole M. Gatto Anne Renz Sarah E. Tom Mary Lyons Jennifer A. Macuiba Tammy S. Dodd Bonnie K. Lind Shelly L. Gray Kelly Meyers Eric B. Larson Jennifer C. Nelson Linda K. McEvoy Sundary Sankaran Dustin Key Jeremiah A. Litondo Paul K. Crane |
| author_facet | Nicole M. Gatto Anne Renz Sarah E. Tom Mary Lyons Jennifer A. Macuiba Tammy S. Dodd Bonnie K. Lind Shelly L. Gray Kelly Meyers Eric B. Larson Jennifer C. Nelson Linda K. McEvoy Sundary Sankaran Dustin Key Jeremiah A. Litondo Paul K. Crane |
| author_sort | Nicole M. Gatto |
| collection | DOAJ |
| description | Background: Adult Changes in Thought (ACT), a prospective cohort study, enrolls older adult members of Kaiser Permanente Washington. We describe an ambitious project to abstract medical records facilitating epidemiological investigation. Methods: Abstracted data include medications; laboratory results; women’s health; blood pressure; physical injuries; cardiovascular, neurological, psychiatric and other medical conditions. Results: Of 1419 of 5763 participants with completed abstractions, 1387 (97.7%) were deceased; 602 (42.4%) were diagnosed with Alzheimer’s Disease and Related Dementias; 985 (69.4%) had a brain autopsy. Each participant had an average of 34.3 (SD = 13.4) years of data abstracted. Over 64% had pharmacy data preceding 1977; 87.5% had laboratory data preceding 1988. Stroke, anxiety, depression and confusion during hospitalization were common among participants diagnosed with dementia. Conclusions: Medical records are transformed into data for analyses with outcomes derived from other ACT data. We provide detailed, unparalleled longitudinal clinical data to support a variety of epidemiological research on clinical-pathological correlations. |
| format | Article |
| id | doaj-art-8864eb05fb73452cbb7b6e0dddf45220 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-8864eb05fb73452cbb7b6e0dddf452202024-11-26T17:54:52ZengMDPI AGBrain Sciences2076-34252024-10-011411107510.3390/brainsci14111075The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related DementiasNicole M. Gatto0Anne Renz1Sarah E. Tom2Mary Lyons3Jennifer A. Macuiba4Tammy S. Dodd5Bonnie K. Lind6Shelly L. Gray7Kelly Meyers8Eric B. Larson9Jennifer C. Nelson10Linda K. McEvoy11Sundary Sankaran12Dustin Key13Jeremiah A. Litondo14Paul K. Crane15Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAColumbia University Irving Medical Center, New York, NY 10032, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USASchool of Pharmacy, University of Washington, Seattle, WA 98102, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USAKaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USASchool of Medicine, University of Washington, Seattle, WA 98195, USABackground: Adult Changes in Thought (ACT), a prospective cohort study, enrolls older adult members of Kaiser Permanente Washington. We describe an ambitious project to abstract medical records facilitating epidemiological investigation. Methods: Abstracted data include medications; laboratory results; women’s health; blood pressure; physical injuries; cardiovascular, neurological, psychiatric and other medical conditions. Results: Of 1419 of 5763 participants with completed abstractions, 1387 (97.7%) were deceased; 602 (42.4%) were diagnosed with Alzheimer’s Disease and Related Dementias; 985 (69.4%) had a brain autopsy. Each participant had an average of 34.3 (SD = 13.4) years of data abstracted. Over 64% had pharmacy data preceding 1977; 87.5% had laboratory data preceding 1988. Stroke, anxiety, depression and confusion during hospitalization were common among participants diagnosed with dementia. Conclusions: Medical records are transformed into data for analyses with outcomes derived from other ACT data. We provide detailed, unparalleled longitudinal clinical data to support a variety of epidemiological research on clinical-pathological correlations.https://www.mdpi.com/2076-3425/14/11/1075chart abstractionhistorical datacomorbiditiesdementiaAlzheimer’s diseaseelectronic health record data |
| spellingShingle | Nicole M. Gatto Anne Renz Sarah E. Tom Mary Lyons Jennifer A. Macuiba Tammy S. Dodd Bonnie K. Lind Shelly L. Gray Kelly Meyers Eric B. Larson Jennifer C. Nelson Linda K. McEvoy Sundary Sankaran Dustin Key Jeremiah A. Litondo Paul K. Crane The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias Brain Sciences chart abstraction historical data comorbidities dementia Alzheimer’s disease electronic health record data |
| title | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias |
| title_full | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias |
| title_fullStr | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias |
| title_full_unstemmed | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias |
| title_short | The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer’s Disease and Related Dementias |
| title_sort | adult changes in thought act medical records abstraction project a resource for research on biological psychosocial and behavioral factors on the aging brain and alzheimer s disease and related dementias |
| topic | chart abstraction historical data comorbidities dementia Alzheimer’s disease electronic health record data |
| url | https://www.mdpi.com/2076-3425/14/11/1075 |
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