Safety assessment of microwave ablation in sheep vertebral bodies
Background Spine is the most common location for bone metastases. Microwave ablation (MWA) is a technique for minimally invasive tumor treatment. The aim of the current study was to determine whether MWA is a safe option for treatment in vertebral bodies and to gain data on the amount of cortical in...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2434607 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560904108343296 |
|---|---|
| author | Hendricus Nijland Jinwen Zhu Thomas Kwee Ding-Jun Hao Paul Jutte |
| author_facet | Hendricus Nijland Jinwen Zhu Thomas Kwee Ding-Jun Hao Paul Jutte |
| author_sort | Hendricus Nijland |
| collection | DOAJ |
| description | Background Spine is the most common location for bone metastases. Microwave ablation (MWA) is a technique for minimally invasive tumor treatment. The aim of the current study was to determine whether MWA is a safe option for treatment in vertebral bodies and to gain data on the amount of cortical insulation in the spine.Method MWA was applied with different settings for power and time in both in- and ex-vivo sheep vertebral bodies. Safety was evaluated by temperature measurements at critical surrounding structures (e.g. spinal cord, nerve root). Furthermore, the distribution of heat through the bone at 5 mm from the ablation needle was measured and compared to the temperature at the posterior wall.Results An effect of cortical insulation in the spine was found, for ablations with 20–30 and 50 W (p < 0.01). Ablations with wattage levels of 40–50 W almost instantly led to temperatures over 60 °C at the posterior wall. The temperature remained below 60 °C for 4 min in ex-vivo ablations with 20 and 30 W. However, in the in-vivo experiment paralysis was frequently seen (10/12 sheep) in lower wattages (20–30 W) as well and the experiment was therefore terminated.Conclusion MWA is an effective approach for local bone destruction in the spine. However, given the high risk of complications, caution is advised for treatment in vertebral bodies without better local distribution accuracy. Since cortical insulation appears insufficient to protect the spinal canal from excess heat, MWA involves a risk of paralysis. |
| format | Article |
| id | doaj-art-8832bb78e20746ce88bbcd74f0932dbb |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-8832bb78e20746ce88bbcd74f0932dbb2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2434607Safety assessment of microwave ablation in sheep vertebral bodiesHendricus Nijland0Jinwen Zhu1Thomas Kwee2Ding-Jun Hao3Paul Jutte4Department of Orthopaedic Surgery, University Medical Center Groningen, Groningen, The NetherlandsDepartment of Orthopaedic Surgery, Xi’an Honghui Hospital, Xi’an, ChinaDepartment of Radiology, University Medical Center Groningen, Groningen, The NetherlandsDepartment of Orthopaedic Surgery, Xi’an Honghui Hospital, Xi’an, ChinaDepartment of Orthopaedic Surgery, University Medical Center Groningen, Groningen, The NetherlandsBackground Spine is the most common location for bone metastases. Microwave ablation (MWA) is a technique for minimally invasive tumor treatment. The aim of the current study was to determine whether MWA is a safe option for treatment in vertebral bodies and to gain data on the amount of cortical insulation in the spine.Method MWA was applied with different settings for power and time in both in- and ex-vivo sheep vertebral bodies. Safety was evaluated by temperature measurements at critical surrounding structures (e.g. spinal cord, nerve root). Furthermore, the distribution of heat through the bone at 5 mm from the ablation needle was measured and compared to the temperature at the posterior wall.Results An effect of cortical insulation in the spine was found, for ablations with 20–30 and 50 W (p < 0.01). Ablations with wattage levels of 40–50 W almost instantly led to temperatures over 60 °C at the posterior wall. The temperature remained below 60 °C for 4 min in ex-vivo ablations with 20 and 30 W. However, in the in-vivo experiment paralysis was frequently seen (10/12 sheep) in lower wattages (20–30 W) as well and the experiment was therefore terminated.Conclusion MWA is an effective approach for local bone destruction in the spine. However, given the high risk of complications, caution is advised for treatment in vertebral bodies without better local distribution accuracy. Since cortical insulation appears insufficient to protect the spinal canal from excess heat, MWA involves a risk of paralysis.https://www.tandfonline.com/doi/10.1080/02656736.2024.2434607Microwave ablationspinevertebral bodiessafetycortical insulation |
| spellingShingle | Hendricus Nijland Jinwen Zhu Thomas Kwee Ding-Jun Hao Paul Jutte Safety assessment of microwave ablation in sheep vertebral bodies International Journal of Hyperthermia Microwave ablation spine vertebral bodies safety cortical insulation |
| title | Safety assessment of microwave ablation in sheep vertebral bodies |
| title_full | Safety assessment of microwave ablation in sheep vertebral bodies |
| title_fullStr | Safety assessment of microwave ablation in sheep vertebral bodies |
| title_full_unstemmed | Safety assessment of microwave ablation in sheep vertebral bodies |
| title_short | Safety assessment of microwave ablation in sheep vertebral bodies |
| title_sort | safety assessment of microwave ablation in sheep vertebral bodies |
| topic | Microwave ablation spine vertebral bodies safety cortical insulation |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2434607 |
| work_keys_str_mv | AT hendricusnijland safetyassessmentofmicrowaveablationinsheepvertebralbodies AT jinwenzhu safetyassessmentofmicrowaveablationinsheepvertebralbodies AT thomaskwee safetyassessmentofmicrowaveablationinsheepvertebralbodies AT dingjunhao safetyassessmentofmicrowaveablationinsheepvertebralbodies AT pauljutte safetyassessmentofmicrowaveablationinsheepvertebralbodies |