The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer
Objective: To compare the effectiveness of combined (indocyanine green [ICG]+ blue dye) tracing versus blue dye alone in guiding sentinel lymph node biopsy (SLNB) in breast cancer. Methods: A total of 112 female patients (mean ± SD age: 51.9 ± 11.9 years) with clinically node-negative (cN0) early-st...
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Elsevier
2024-12-01
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| Series: | Asian Journal of Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S101595842401460X |
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| author | Ercument Gurluler Volkan Polatkan Kazim Senol Mustafa Sehsuvar Gokgoz |
| author_facet | Ercument Gurluler Volkan Polatkan Kazim Senol Mustafa Sehsuvar Gokgoz |
| author_sort | Ercument Gurluler |
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| description | Objective: To compare the effectiveness of combined (indocyanine green [ICG]+ blue dye) tracing versus blue dye alone in guiding sentinel lymph node biopsy (SLNB) in breast cancer. Methods: A total of 112 female patients (mean ± SD age: 51.9 ± 11.9 years) with clinically node-negative (cN0) early-stage breast cancer were evaluated based on SLN tracing technique including methylene blue + ICG (n = 17), isosulfan blue + ICG (n = 19) and methylene blue alone (n = 76). Mapping patterns of each SLN, the number of total lymph nodes (TLNs) removed, including metastatic and hyperplastic lymph nodes, and the metastatic lymph node detection rate were analyzed for each tracing technique. Results: SLN detection rate was 100 % with complementary use of ICG. No significant difference was noted between methylene blue + ICG, isosulfan + ICG and methylene blue alone groups in terms of the mean ± SD number of TLNs removed (3.9 ± 2.5, 4.7 ± 3 and 3.7 ± 2.3, respectively) and metastatic lymph node detection rates (16.0 %, 16.25 % and 13.98 %, respectively). Complementary use of ICG revealed the N0 stage for 66.6 % of cases considered as Nx (cannot be detected) on blue dye alone. Also, 20.0 % of N0 and 11.1 % of N1 cases on blue dye were diagnosed with more advance nodal status (N1 and N2 respectively) after complementary use of ICG. Conclusions: The combined tracing (ICG + blue dye) seems valuable not only in terms of the SLN detection rates and lymph node yield but also has an added value in providing more accurate nodal stating and thus a proper final tumor staging with considerable therapeutic implications. |
| format | Article |
| id | doaj-art-881e7abd16f947f88d0b3e9cb6c6fcf1 |
| institution | Kabale University |
| issn | 1015-9584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Asian Journal of Surgery |
| spelling | doaj-art-881e7abd16f947f88d0b3e9cb6c6fcf12024-11-30T07:09:36ZengElsevierAsian Journal of Surgery1015-95842024-12-01471251315136The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancerErcument Gurluler0Volkan Polatkan1Kazim Senol2Mustafa Sehsuvar Gokgoz3Corresponding author. Department of General Surgery, Uludag University Faculty of Medicine, Görükle Kampüsü, 16059, Nilüfer, Bursa, Turkey.; Department of General Surgery, Bursa Uludag University Faculty of Medicine, Bursa, TurkeyDepartment of General Surgery, Bursa Uludag University Faculty of Medicine, Bursa, TurkeyDepartment of General Surgery, Bursa Uludag University Faculty of Medicine, Bursa, TurkeyDepartment of General Surgery, Bursa Uludag University Faculty of Medicine, Bursa, TurkeyObjective: To compare the effectiveness of combined (indocyanine green [ICG]+ blue dye) tracing versus blue dye alone in guiding sentinel lymph node biopsy (SLNB) in breast cancer. Methods: A total of 112 female patients (mean ± SD age: 51.9 ± 11.9 years) with clinically node-negative (cN0) early-stage breast cancer were evaluated based on SLN tracing technique including methylene blue + ICG (n = 17), isosulfan blue + ICG (n = 19) and methylene blue alone (n = 76). Mapping patterns of each SLN, the number of total lymph nodes (TLNs) removed, including metastatic and hyperplastic lymph nodes, and the metastatic lymph node detection rate were analyzed for each tracing technique. Results: SLN detection rate was 100 % with complementary use of ICG. No significant difference was noted between methylene blue + ICG, isosulfan + ICG and methylene blue alone groups in terms of the mean ± SD number of TLNs removed (3.9 ± 2.5, 4.7 ± 3 and 3.7 ± 2.3, respectively) and metastatic lymph node detection rates (16.0 %, 16.25 % and 13.98 %, respectively). Complementary use of ICG revealed the N0 stage for 66.6 % of cases considered as Nx (cannot be detected) on blue dye alone. Also, 20.0 % of N0 and 11.1 % of N1 cases on blue dye were diagnosed with more advance nodal status (N1 and N2 respectively) after complementary use of ICG. Conclusions: The combined tracing (ICG + blue dye) seems valuable not only in terms of the SLN detection rates and lymph node yield but also has an added value in providing more accurate nodal stating and thus a proper final tumor staging with considerable therapeutic implications.http://www.sciencedirect.com/science/article/pii/S101595842401460XBreast cancerSentinel lymph node biopsyIndocyanine greenLymph node yieldAxillary staging |
| spellingShingle | Ercument Gurluler Volkan Polatkan Kazim Senol Mustafa Sehsuvar Gokgoz The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer Asian Journal of Surgery Breast cancer Sentinel lymph node biopsy Indocyanine green Lymph node yield Axillary staging |
| title | The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer |
| title_full | The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer |
| title_fullStr | The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer |
| title_full_unstemmed | The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer |
| title_short | The feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer |
| title_sort | feasibility and added value of indocyanine green tracing in guiding sentinel lymph node biopsy for breast cancer |
| topic | Breast cancer Sentinel lymph node biopsy Indocyanine green Lymph node yield Axillary staging |
| url | http://www.sciencedirect.com/science/article/pii/S101595842401460X |
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