Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer

Unveiling the role of ASPP1 in cancer progression: pan-cancer bioinformatics and experimental validation in colorectal cancer

BackgroundThe Apoptosis-Stimulating Protein of P53 (ASPP) family contributes to apoptosis regulation and tumor suppression, with ASPP1 influencing processes like cancer cell proliferation, invasion, and migration. Its expression varies across cancer types, suggesting a potential role in oncogenesis....

Full description

Saved in:

Bibliographic Details
Main Authors:	Keyuan Xiao, Xiang Li, Ihsan Ullah, Wenqing Hu, Kaiqiang Wang, Fan Yang, Chengyu Yang, Chunqi Feng, Liang Zong, Xinghua Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Oncology
Subjects:	ASPP1 pan-cancer analysis tumor suppression immune modulation colorectal cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1529809/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Pan-cancer analysis of CLDN1 and its functional study in gastric cancer
by: Zhu Weijing, et al.
Published: (2024-12-01)

A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response
by: Minghan Li, et al.
Published: (2025-01-01)

A comprehensive pan-cancer analysis of RNF187 in human tumors
by: Xuezhong Zhang, et al.
Published: (2025-01-01)

Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB
by: Bai Y, et al.
Published: (2025-01-01)

Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics
by: Lihe Jiang, et al.
Published: (2025-01-01)

A generative deep neural network for pan-digestive tract cancer survival analysis
by: Lekai Xu, et al.
Published: (2025-01-01)

WeiFu: A Novel Pan-Cancer Driver Gene Identification Method Using Incidence-Weighted Mutation Scores
by: Yanjie Ren, et al.
Published: (2024-01-01)

Comprehensive analysis of the prognostic, immunological, and diagnostic roles of SIRT1 in pan-cancer and its validation in KIRC
by: Qi Liu, et al.
Published: (2025-01-01)

Pan-cancer characterization of m6A-mediated regulation of T cell exhaustion dynamics and clinical relevancies in human cancers
by: Weiping Ji, et al.
Published: (2025-03-01)

Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer
by: Zhaoda Deng, et al.
Published: (2025-01-01)

Integrative pan-cancer analysis and experiment validation identified GLS as a biomarker in tumor progression, prognosis, immune microenvironment, and immunotherapy
by: Dongming Li, et al.
Published: (2025-01-01)

Comprehensive pan-cancer analysis reveals NTN1 as an immune infiltrate risk factor and its potential prognostic value in SKCM
by: Fuxiang Luan, et al.
Published: (2025-01-01)

Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC
by: Tao Zhou, et al.
Published: (2025-01-01)

Pan-cancer analysis and single-cell analysis identifies the CENPN as a biomarker for survival prognosis and immunotherapy
by: Nie Zhang, et al.
Published: (2025-01-01)

Pan-Cancer Analysis of Disulfidptosis-Related Genes Affecting Prognosis and Tumor Microenvironment
by: Jingyang SUN, et al.
Published: (2025-01-01)

Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer
by: Jinlong Tian, et al.
Published: (2025-01-01)

Identification of ASF1B as a prognostic marker for liver cancer by meta-analysis and its immune value revealed by a comprehensive pan-cancer analysis of 33 human cancers
by: Yiyang Chen, et al.
Published: (2023-01-01)

Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas
by: Junhao Zhang, et al.
Published: (2025-01-01)

Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis
by: Qian Guo, et al.
Published: (2025-01-01)

Pan-cancer analysis of SOX2: Prognostic implications and potential as a therapeutic target in immune checkpoint modulation
by: Shoukai Yu, et al.
Published: (2025-02-01)

ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation
by: Jiaxing Zhang, et al.
Published: (2025-02-01)

A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features
by: Zihan Quan, et al.
Published: (2025-12-01)

Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma
by: Zhecheng Li, et al.
Published: (2024-09-01)

Prospective clinical evidence from over 1,000 pan-cancer patients: a complement to fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting
by: Lijuan He, et al.
Published: (2025-01-01)

Prospective roles of sirtuin 1 (SIRT1) in oral cancer therapy
by: Rekha Thiruvengadam, et al.
Published: (2024-06-01)

A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment
by: Yuanhui Wang, et al.
Published: (2025-02-01)

The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases
by: Yezhou Ding, et al.
Published: (2025-01-01)

Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma
by: Guohong Yan, et al.
Published: (2025-01-01)

Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological function
by: Zhu Liu, et al.
Published: (2025-01-01)

Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome
by: Jingru Sui, et al.
Published: (2025-01-01)

Pan-cancer and experimental analyses reveal the immunotherapeutic significance of CST2 and its association with stomach adenocarcinoma proliferation and metastasis
by: Dan Huang, et al.
Published: (2025-01-01)

CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target
by: Cong Xiao, et al.
Published: (2024-12-01)

Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC
by: Chenxuan Li, et al.
Published: (2025-03-01)

Elucidating the expression and role of cGAS in pan-cancer using integrated bioinformatics and experimental approaches
by: Zhen Lian, et al.
Published: (2025-01-01)

Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis
by: Wen-Run Cai, et al.
Published: (2025-02-01)

Mathematical modeling of continuous and intermittent androgen suppression for the treatment of advanced prostate cancer
by: Alacia M. Voth, et al.
Published: (2017-05-01)

Potential role of P4HB in the tumor microenvironment and its clinical prognostic value: a comprehensive pan-cancer analysis and experimental validation with a focus on KIRC
by: Linxue Zhang, et al.
Published: (2025-01-01)

Pan-cancer drivers of metastasis
by: Ryan Lusby, et al.
Published: (2025-01-01)

Gender, FT4 levels, T stage, and BMI as predictors of TSH levels in thyroid cancer patients
by: Sen Zhang, et al.
Published: (2025-01-01)

Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes
by: Mengmeng Sang, et al.
Published: (2025-01-01)