Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model

Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model

IntroductionPeripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis injuries requiring complex therapeutic interventions to restore functionality. This study aimed to evaluate the pro-regenerative potential of combining neural guide conduits with conditi...

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Main Authors: Rui Alvites, Bruna Lopes, André Coelho, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Alexandra Rêma, Maria Simões, Carla Mendonça, Luís Atayde, Justina Prada, Isabel Pires, Bruna Silva, Filipa João, Miriam Metafune, Francesca Bertone, Stefania Raimondo, Nuno Alves, Ana Lúcia Luís, Ana Colette Maurício
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
peripheral nerve injury
peripheral nerve regeneration
common peroneal nerve
animal model
sheep model
cell-based therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1598736/full
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