Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance
Abstract Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis therapeutic agents and the achievement of efficient copper release are critical steps forward. Herein, closely‐contacted Cu2O‐CoWO4 nano...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410621 |
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| author | Zhuoran Yang Zhuo Li Chunyu Yang Li Meng Wei Guo Liqiang Jing |
| author_facet | Zhuoran Yang Zhuo Li Chunyu Yang Li Meng Wei Guo Liqiang Jing |
| author_sort | Zhuoran Yang |
| collection | DOAJ |
| description | Abstract Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis therapeutic agents and the achievement of efficient copper release are critical steps forward. Herein, closely‐contacted Cu2O‐CoWO4 nanosheet heterojunctions (CCW‐NH) are successfully synthesized using an in‐situ process for cuproptosis therapy. The efficient release of copper ions from CCW‐NH can be triggered by ultrasound irradiation, primarily due to the generation of superoxide radicals as the sonodynamic agents via the Z‐scheme charge transfer mechanism. When subjected to the combined effects of ultrasound and laser irradiation, the effective release of copper ions is increased by 1.7 times compared to the untreated group, significantly enhancing the efficiency of cuproptosis. And the incorporation of CCW‐NH and L‐arginine into the temperature‐sensitive injectable hydrogel (HP‐CCW@LA) ultimately achieved a tumor inhibition rate of up to 95.1%. L‐arginine, serving as a reducing agent, enabled the sustained release of highly active Cu+ during treatment. Notably, after treating tumors with HP‐CCW@LA, the tumor microenvironment is leveraged to promote copper ion conversion, which offers the potential for monitoring tumor therapy efficacy through magnetic resonance imaging. This work offers a novel integrated strategy for the development of new cuproptosis agents and therapeutic evaluation. |
| format | Article |
| id | doaj-art-87de4532bd1b45aa857cf38bb87d4e44 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-87de4532bd1b45aa857cf38bb87d4e442025-01-13T15:29:43ZengWileyAdvanced Science2198-38442025-01-01122n/an/a10.1002/advs.202410621Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal AssistanceZhuoran Yang0Zhuo Li1Chunyu Yang2Li Meng3Wei Guo4Liqiang Jing5Key Laboratory of Photochemical Biomaterials and Energy Storage Materials Heilongjiang Province and College of Chemistry and Chemical Engineering Harbin Normal University Harbin 150025 ChinaKey Laboratory of Functional Inorganic Materials Chemistry (Ministry of Education) School of Chemistry and Materials Science International Joint Research Center for Catalytic Technology Heilongjiang University Harbin 150080 ChinaKey Laboratory of Photochemical Biomaterials and Energy Storage Materials Heilongjiang Province and College of Chemistry and Chemical Engineering Harbin Normal University Harbin 150025 ChinaKey Laboratory of Functional Inorganic Materials Chemistry (Ministry of Education) School of Chemistry and Materials Science International Joint Research Center for Catalytic Technology Heilongjiang University Harbin 150080 ChinaKey Laboratory of Photochemical Biomaterials and Energy Storage Materials Heilongjiang Province and College of Chemistry and Chemical Engineering Harbin Normal University Harbin 150025 ChinaKey Laboratory of Functional Inorganic Materials Chemistry (Ministry of Education) School of Chemistry and Materials Science International Joint Research Center for Catalytic Technology Heilongjiang University Harbin 150080 ChinaAbstract Cuproptosis offers a promising and selective therapeutic strategy for cancer therapy. To fully realize its potential, the development of novel cuproptosis therapeutic agents and the achievement of efficient copper release are critical steps forward. Herein, closely‐contacted Cu2O‐CoWO4 nanosheet heterojunctions (CCW‐NH) are successfully synthesized using an in‐situ process for cuproptosis therapy. The efficient release of copper ions from CCW‐NH can be triggered by ultrasound irradiation, primarily due to the generation of superoxide radicals as the sonodynamic agents via the Z‐scheme charge transfer mechanism. When subjected to the combined effects of ultrasound and laser irradiation, the effective release of copper ions is increased by 1.7 times compared to the untreated group, significantly enhancing the efficiency of cuproptosis. And the incorporation of CCW‐NH and L‐arginine into the temperature‐sensitive injectable hydrogel (HP‐CCW@LA) ultimately achieved a tumor inhibition rate of up to 95.1%. L‐arginine, serving as a reducing agent, enabled the sustained release of highly active Cu+ during treatment. Notably, after treating tumors with HP‐CCW@LA, the tumor microenvironment is leveraged to promote copper ion conversion, which offers the potential for monitoring tumor therapy efficacy through magnetic resonance imaging. This work offers a novel integrated strategy for the development of new cuproptosis agents and therapeutic evaluation.https://doi.org/10.1002/advs.202410621copper ion releaseCu2O‐CoWO4 nanocompositephotothermal therapysonodynamic therapytumor therapy |
| spellingShingle | Zhuoran Yang Zhuo Li Chunyu Yang Li Meng Wei Guo Liqiang Jing Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance Advanced Science copper ion release Cu2O‐CoWO4 nanocomposite photothermal therapy sonodynamic therapy tumor therapy |
| title | Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance |
| title_full | Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance |
| title_fullStr | Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance |
| title_full_unstemmed | Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance |
| title_short | Synthesis of Closely‐Contacted Cu2O‐CoWO4 Nanosheet Composites for Cuproptosis Therapy to Tumors With Sonodynamic and Photothermal Assistance |
| title_sort | synthesis of closely contacted cu2o cowo4 nanosheet composites for cuproptosis therapy to tumors with sonodynamic and photothermal assistance |
| topic | copper ion release Cu2O‐CoWO4 nanocomposite photothermal therapy sonodynamic therapy tumor therapy |
| url | https://doi.org/10.1002/advs.202410621 |
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