Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study

Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study

Abstract Haptoglobin (Hp) scavenges cell-free hemoglobin and correlates with the prognosis of human sepsis, a life-threatening systemic inflammatory condition. Despite extensive research on Hp glycosylation as a glyco-biomarker for cancers, understanding glycosylated modifications of Hp in sepsis pa...

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Main Authors: Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56524-3
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