Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential
Stilbenoids are a category of plant compounds exhibiting notable health-related benefits. After resveratrol, perhaps the most well-known stilbenoid is pinosylvin, a major phytochemical constituent of most plants characterised by the pine spines among others. Pinosylvin and its derivatives have been...
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2025-03-01
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| author | Argyrios Periferakis Aristodemos-Theodoros Periferakis Lamprini Troumpata Konstantinos Periferakis Spyrangelos Georgatos-Garcia Georgia Touriki Christiana Diana Maria Dragosloveanu Ana Caruntu Ilinca Savulescu-Fiedler Serban Dragosloveanu Andreea-Elena Scheau Ioana Anca Badarau Constantin Caruntu Cristian Scheau |
| author_facet | Argyrios Periferakis Aristodemos-Theodoros Periferakis Lamprini Troumpata Konstantinos Periferakis Spyrangelos Georgatos-Garcia Georgia Touriki Christiana Diana Maria Dragosloveanu Ana Caruntu Ilinca Savulescu-Fiedler Serban Dragosloveanu Andreea-Elena Scheau Ioana Anca Badarau Constantin Caruntu Cristian Scheau |
| author_sort | Argyrios Periferakis |
| collection | DOAJ |
| description | Stilbenoids are a category of plant compounds exhibiting notable health-related benefits. After resveratrol, perhaps the most well-known stilbenoid is pinosylvin, a major phytochemical constituent of most plants characterised by the pine spines among others. Pinosylvin and its derivatives have been found to exert potent antibacterial and antifungal effects, while their antiparasitic and antiviral properties are still a subject of ongoing research. The antioxidant properties of pinosylvin are mostly based on its scavenging of free radicals, inhibition of iNOS and protein kinase C, and promotion of HO-1 expression. Its anti-inflammatory properties are based on a variety of mechanisms, such as COX-2 inhibition, NF-κB and TRPA1 activation inhibition, and reduction in IL-6 levels. Its anticancer properties are partly associated with its antioxidant and anti-inflammatory potential, although a number of other mechanisms are described, such as apoptosis induction and matrix metalloproteinase inhibition. A couple of experiments have also suggested a neuroprotective potential. A multitude of ethnomedical and ethnobotanical effects of pinosylvin-containing plants are reported, like antimicrobial, antioxidant, anti-inflammatory, hepatoprotective, and prokinetic actions; many of these are corroborated by recent research. The advent of novel methods of artificial pinosylvin synthesis may facilitate its mass production and adoption as a medical compound. Finally, pinosylvin may be a tool in promoting environmentally friendly pesticide and insecticide policies and be used in land remediation schemes. |
| format | Article |
| id | doaj-art-878c98cf98c541ae9018e3fcf12e96e6 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-878c98cf98c541ae9018e3fcf12e96e62025-08-20T03:43:02ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-03-0147320410.3390/cimb47030204Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory PotentialArgyrios Periferakis0Aristodemos-Theodoros Periferakis1Lamprini Troumpata2Konstantinos Periferakis3Spyrangelos Georgatos-Garcia4Georgia Touriki5Christiana Diana Maria Dragosloveanu6Ana Caruntu7Ilinca Savulescu-Fiedler8Serban Dragosloveanu9Andreea-Elena Scheau10Ioana Anca Badarau11Constantin Caruntu12Cristian Scheau13Department of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaAkadimia of Ancient Greek and Traditional Chinese Medicine, 16675 Athens, GreeceTilburg Institute for Law, Technology, and Society (TILT), Tilburg University, 5037 DE Tilburg, The NetherlandsFaculty of Law, Democritus University of Thrace, 69100 Komotini, GreeceDepartment of Ophthalmology, Faculty of Dentistry, The “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Oral and Maxillofacial Surgery, “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, RomaniaDepartment of Internal Medicine, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Orthopaedics and Traumatology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Radiology and Medical Imaging, “Foisor” Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaStilbenoids are a category of plant compounds exhibiting notable health-related benefits. After resveratrol, perhaps the most well-known stilbenoid is pinosylvin, a major phytochemical constituent of most plants characterised by the pine spines among others. Pinosylvin and its derivatives have been found to exert potent antibacterial and antifungal effects, while their antiparasitic and antiviral properties are still a subject of ongoing research. The antioxidant properties of pinosylvin are mostly based on its scavenging of free radicals, inhibition of iNOS and protein kinase C, and promotion of HO-1 expression. Its anti-inflammatory properties are based on a variety of mechanisms, such as COX-2 inhibition, NF-κB and TRPA1 activation inhibition, and reduction in IL-6 levels. Its anticancer properties are partly associated with its antioxidant and anti-inflammatory potential, although a number of other mechanisms are described, such as apoptosis induction and matrix metalloproteinase inhibition. A couple of experiments have also suggested a neuroprotective potential. A multitude of ethnomedical and ethnobotanical effects of pinosylvin-containing plants are reported, like antimicrobial, antioxidant, anti-inflammatory, hepatoprotective, and prokinetic actions; many of these are corroborated by recent research. The advent of novel methods of artificial pinosylvin synthesis may facilitate its mass production and adoption as a medical compound. Finally, pinosylvin may be a tool in promoting environmentally friendly pesticide and insecticide policies and be used in land remediation schemes.https://www.mdpi.com/1467-3045/47/3/204pinosylvinantimicrobial effectsantioxidantanti-inflammatoryanticancerethnomedicine |
| spellingShingle | Argyrios Periferakis Aristodemos-Theodoros Periferakis Lamprini Troumpata Konstantinos Periferakis Spyrangelos Georgatos-Garcia Georgia Touriki Christiana Diana Maria Dragosloveanu Ana Caruntu Ilinca Savulescu-Fiedler Serban Dragosloveanu Andreea-Elena Scheau Ioana Anca Badarau Constantin Caruntu Cristian Scheau Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential Current Issues in Molecular Biology pinosylvin antimicrobial effects antioxidant anti-inflammatory anticancer ethnomedicine |
| title | Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential |
| title_full | Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential |
| title_fullStr | Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential |
| title_full_unstemmed | Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential |
| title_short | Pinosylvin: A Multifunctional Stilbenoid with Antimicrobial, Antioxidant, and Anti-Inflammatory Potential |
| title_sort | pinosylvin a multifunctional stilbenoid with antimicrobial antioxidant and anti inflammatory potential |
| topic | pinosylvin antimicrobial effects antioxidant anti-inflammatory anticancer ethnomedicine |
| url | https://www.mdpi.com/1467-3045/47/3/204 |
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