Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients

Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients

PurposeThe incidence of hemodynamic instability associated with dexmedetomidine (DEX) sedation has been reported to exceed 50%, with substantial inter-individual variability in response. Genetic factors have been suggested to contribute significantly to such variation. The aim of this study was to i...

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Bibliographic Details
Main Authors: Yanping Guan, Bilian Li, Yiyu Zhang, Hao Luo, Xueding Wang, Xue Bai, Zhuoling Zheng, Yaying Huang, Wei Wei, Min Huang, Xingrong Song, Guoping Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
dexmedetomidine
hemodynamic instability
single-nucleotide polymorphism
pharmacokinetics
pediatric anesthesia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1515523/full
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