Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer
Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional me...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117722911 |
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| _version_ | 1841563226361298944 |
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| author | Jun He MD Leping Yang MD Wenjun Yi MD Wentao Fan MD Yu Wen MD Xiongying Miao MD Li Xiong MD |
| author_facet | Jun He MD Leping Yang MD Wenjun Yi MD Wentao Fan MD Yu Wen MD Xiongying Miao MD Li Xiong MD |
| author_sort | Jun He MD |
| collection | DOAJ |
| description | Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imaging in the operating room. Recent advancements in contrast agents and intraoperative fluorescence imaging devices have led to a greater potential for intraoperative fluorescence imaging in clinical applications. Photodynamic therapy (PDT) is an alternative modality to treat tumors, which uses a light-sensitive drug (photosensitizers) and special light to destroy the targeted tissues. In this review, we discuss the fluorescent contrast agents, some newly developed imaging devices, and the successful clinical application of FGS. Additionally, we present the combined strategy of FGS with PDT to further improve the therapeutic effect for patients with cancer. Taken together, this review provides a unique perspective and summarization of FGS. |
| format | Article |
| id | doaj-art-873e3e5b4f8c462b9528b4f729286e71 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-873e3e5b4f8c462b9528b4f729286e712025-01-03T00:10:27ZengSAGE PublishingMolecular Imaging1536-01212017-08-011610.1177/1536012117722911Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of CancerJun He MD0Leping Yang MD1Wenjun Yi MD2Wentao Fan MD3Yu Wen MD4Xiongying Miao MD5Li Xiong MD6 General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, China General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, China General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, China General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, China General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, China General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, China General Surgery Department, Second Xiangya Hospital, Central South University, Changsha, ChinaSpecific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imaging in the operating room. Recent advancements in contrast agents and intraoperative fluorescence imaging devices have led to a greater potential for intraoperative fluorescence imaging in clinical applications. Photodynamic therapy (PDT) is an alternative modality to treat tumors, which uses a light-sensitive drug (photosensitizers) and special light to destroy the targeted tissues. In this review, we discuss the fluorescent contrast agents, some newly developed imaging devices, and the successful clinical application of FGS. Additionally, we present the combined strategy of FGS with PDT to further improve the therapeutic effect for patients with cancer. Taken together, this review provides a unique perspective and summarization of FGS.https://doi.org/10.1177/1536012117722911 |
| spellingShingle | Jun He MD Leping Yang MD Wenjun Yi MD Wentao Fan MD Yu Wen MD Xiongying Miao MD Li Xiong MD Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer Molecular Imaging |
| title | Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer |
| title_full | Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer |
| title_fullStr | Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer |
| title_full_unstemmed | Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer |
| title_short | Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer |
| title_sort | combination of fluorescence guided surgery with photodynamic therapy for the treatment of cancer |
| url | https://doi.org/10.1177/1536012117722911 |
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