Automated, Quantitative Capillary Western Blots to Analyze Host Cell Proteins in COVID-19 Vaccine Produced in Vero Cell Line

Automated, Quantitative Capillary Western Blots to Analyze Host Cell Proteins in COVID-19 Vaccine Produced in Vero Cell Line

Background/Objectives: Host cell protein (HCP) content is a major attribute for biological and vaccine products that must be extensively characterized prior to product licensure. Enzyme Linked Immunosorbent Assay (ELISA) and Mass Spectrometry (MS) are conventional methods for quantitative host cell...

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Bibliographic Details
Main Authors: Paul F. Gillespie, Yanjie Wang, Kuo Yin, Emily Groegler, Nicholas Cunningham, Alyssa Q. Stiving, Jessica Raffaele, Natalia Marusa, Christopher M. Tubbs, John W. Loughney, Michael A. Winters, Richard R. Rustandi
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Vaccines
Subjects:
host cell protein (HCP)
capillary western
Simple Western<sup>TM</sup>
V590
COVID-19
Online Access:https://www.mdpi.com/2076-393X/12/12/1373
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