Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial
Cough is one of the most prevalent symptoms of COVID-19, affecting over 60% of patients. This symptom significantly diminishes quality of life, causing fatigue, insomnia, dysphonia, musculoskeletal pain, and urinary incontinence. Honey Zufa herbal syrup is a well-known antitussive remedy in the Ira...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-11-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/11167 |
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| author | Marziyeh Heydari Hossein Kazemi Zadeh Soha Namazi Hamid Emadi Koochak Nasim Khajavi Rad Mahnaz Khanavi Arman Zargaran |
| author_facet | Marziyeh Heydari Hossein Kazemi Zadeh Soha Namazi Hamid Emadi Koochak Nasim Khajavi Rad Mahnaz Khanavi Arman Zargaran |
| author_sort | Marziyeh Heydari |
| collection | DOAJ |
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Cough is one of the most prevalent symptoms of COVID-19, affecting over 60% of patients. This symptom significantly diminishes quality of life, causing fatigue, insomnia, dysphonia, musculoskeletal pain, and urinary incontinence. Honey Zufa herbal syrup is a well-known antitussive remedy in the Iranian market and was evaluated for its potential to alleviate this symptom. This study aimed to assess the efficacy and safety of Honey Zufa herbal syrup in treating acute cough resulting from mild to moderate COVID-19. A randomized controlled trial was conducted with 200 patients assigned to either the treatment group, receiving Honey Zufa herbal syrup, or the placebo group, receiving a placebo. Both groups also received standard cough control medications. Cough severity was measured using three different scoring systems. The impact of Honey Zufa on cough severity, the influence of other medications, and changes in laboratory parameters were monitored over a 14-day period. Honey Zufa herbal syrup significantly reduced cough severity compared to the placebo across all scoring systems. The treatment group experienced a greater reduction in cough severity than the placebo group. However, there was no significant difference between the groups in terms of antitussive medication regimens. Laboratory parameters remained stable, and no significant side effects were observed. Honey Zufa herbal syrup effectively reduces cough severity in patients with mild to moderate COVID-19, suggesting it could serve as a useful complementary and alternative treatment option for COVID-19-induced cough.
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| format | Article |
| id | doaj-art-870fc0ec74db496eafa758687cb5d4db |
| institution | Kabale University |
| issn | 0044-6025 1735-9694 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj-art-870fc0ec74db496eafa758687cb5d4db2025-01-06T08:34:11ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942024-11-0162310.18502/acta.v62i3.17116Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical TrialMarziyeh Heydari0Hossein Kazemi Zadeh1Soha Namazi2Hamid Emadi Koochak3Nasim Khajavi Rad4Mahnaz Khanavi5Arman Zargaran6Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. AND Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Department of Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran. Cough is one of the most prevalent symptoms of COVID-19, affecting over 60% of patients. This symptom significantly diminishes quality of life, causing fatigue, insomnia, dysphonia, musculoskeletal pain, and urinary incontinence. Honey Zufa herbal syrup is a well-known antitussive remedy in the Iranian market and was evaluated for its potential to alleviate this symptom. This study aimed to assess the efficacy and safety of Honey Zufa herbal syrup in treating acute cough resulting from mild to moderate COVID-19. A randomized controlled trial was conducted with 200 patients assigned to either the treatment group, receiving Honey Zufa herbal syrup, or the placebo group, receiving a placebo. Both groups also received standard cough control medications. Cough severity was measured using three different scoring systems. The impact of Honey Zufa on cough severity, the influence of other medications, and changes in laboratory parameters were monitored over a 14-day period. Honey Zufa herbal syrup significantly reduced cough severity compared to the placebo across all scoring systems. The treatment group experienced a greater reduction in cough severity than the placebo group. However, there was no significant difference between the groups in terms of antitussive medication regimens. Laboratory parameters remained stable, and no significant side effects were observed. Honey Zufa herbal syrup effectively reduces cough severity in patients with mild to moderate COVID-19, suggesting it could serve as a useful complementary and alternative treatment option for COVID-19-induced cough. https://acta.tums.ac.ir/index.php/acta/article/view/11167Persian medicineCOVID-19CoughHerbal medicine |
| spellingShingle | Marziyeh Heydari Hossein Kazemi Zadeh Soha Namazi Hamid Emadi Koochak Nasim Khajavi Rad Mahnaz Khanavi Arman Zargaran Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial Acta Medica Iranica Persian medicine COVID-19 Cough Herbal medicine |
| title | Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial |
| title_full | Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial |
| title_fullStr | Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial |
| title_full_unstemmed | Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial |
| title_short | Evaluation of the Effect of “Honey Zufa” Herbal Syrup on Cough in Hospitalized Patients With COVID-19: A Double Blind Randomized Clinical Trial |
| title_sort | evaluation of the effect of honey zufa herbal syrup on cough in hospitalized patients with covid 19 a double blind randomized clinical trial |
| topic | Persian medicine COVID-19 Cough Herbal medicine |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/11167 |
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