The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia)
BACKGROUND: Coronavirus pandemic (COVID-19) affected antimicrobial stewardship and increased antimicrobial resistance (MDR) of common nosocomial pathogens. Main reasons for this were frequent and uncritical use of antibiotics, regardless of whether the bacterial infection was proven or not, '&#...
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524002236 |
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| author | Predrag Savic Milos Gostimirovic Teodora Vitorovic Jovana Rajkovic Ana Bukarica Ljiljana Gojkovic-Bukarica |
| author_facet | Predrag Savic Milos Gostimirovic Teodora Vitorovic Jovana Rajkovic Ana Bukarica Ljiljana Gojkovic-Bukarica |
| author_sort | Predrag Savic |
| collection | DOAJ |
| description | BACKGROUND: Coronavirus pandemic (COVID-19) affected antimicrobial stewardship and increased antimicrobial resistance (MDR) of common nosocomial pathogens. Main reasons for this were frequent and uncritical use of antibiotics, regardless of whether the bacterial infection was proven or not, ''off-label'' use of antibiotics (e.g viral pneumonia), prolonged hospital stay and outpatient self-administration. Here we analysed how COVID-19 pandemic influenced the incidence and resistance rate of Klebsiella pneumoniae (KPN), Pseudomonas aeruginosa (PAE) and Acinetobacter baumannii (ABA) isolated from blood samples in a tertiary care hospital in Belgrade (Serbia), between 1, April 2019 and 1 April, 2022. METHODS: Identification and susceptibility testing were performed using the Vitek 2 system. The burden of resistance for each antibiotic was calculated as the percentage of all ‘’resistant’’ + ‘’intermediate resistant’’ results among tested isolates from all patients samples. For analysis of susceptibility rates we used the WHONET 5.6 software. RESULTS: Total numbers of all bacterial isolates were 3286, 2685 and 3064, respectively. Out of them, total number of isolates of KPN were 290 (8.8%), 247 (9.2%) and 275 (9%), of PAE were 177 (5.4%), 103 (3.8%) and 104 (6.4%) and of ABA were 144 (4.4%), 323 (12%) and 337 (11%), recpectively. Compared with 2019, KPN showed statistically significant trend of increasing resistance (p<0.001) after pandemic, mostly with meropenem (65.2%), ciprofloxacin (87.6%) and colistin (40.5%). CONCLUSIONS: COVID-19 might have caused increased prevalence and MDR of common pathogens, especially of KPN, which is probably due to the high percent of patients on the mechanical ventilation and prolonged hospital stay. |
| format | Article |
| id | doaj-art-86ef0bb93f974ac9b7d58aa4aa0dd444 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-86ef0bb93f974ac9b7d58aa4aa0dd4442024-12-27T04:08:19ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-013915The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia)Predrag Savic0Milos Gostimirovic1Teodora Vitorovic2Jovana Rajkovic3Ana Bukarica4Ljiljana Gojkovic-Bukarica5University Hospital Dr Dragisa Misovic Dedinje, Belgrade, SerbiaInstitute of pharmacology, clinical pharmacology and toxicology, Faculty of Medicine, University of Belgrade, Belgrade, SerbiaUniversity Hospital Dr Dragisa Misovic Dedinje, Belgrade, SerbiaInstitute of pharmacology, clinical pharmacology and toxicology, Faculty of Medicine, University of Belgrade, Belgrade, SerbiaInstitute for cardiovascular diseases Dedinje, Belgrade, SerbiaInstitute of pharmacology, clinical pharmacology and toxicology, Faculty of Medicine, University of Belgrade, Belgrade, SerbiaBACKGROUND: Coronavirus pandemic (COVID-19) affected antimicrobial stewardship and increased antimicrobial resistance (MDR) of common nosocomial pathogens. Main reasons for this were frequent and uncritical use of antibiotics, regardless of whether the bacterial infection was proven or not, ''off-label'' use of antibiotics (e.g viral pneumonia), prolonged hospital stay and outpatient self-administration. Here we analysed how COVID-19 pandemic influenced the incidence and resistance rate of Klebsiella pneumoniae (KPN), Pseudomonas aeruginosa (PAE) and Acinetobacter baumannii (ABA) isolated from blood samples in a tertiary care hospital in Belgrade (Serbia), between 1, April 2019 and 1 April, 2022. METHODS: Identification and susceptibility testing were performed using the Vitek 2 system. The burden of resistance for each antibiotic was calculated as the percentage of all ‘’resistant’’ + ‘’intermediate resistant’’ results among tested isolates from all patients samples. For analysis of susceptibility rates we used the WHONET 5.6 software. RESULTS: Total numbers of all bacterial isolates were 3286, 2685 and 3064, respectively. Out of them, total number of isolates of KPN were 290 (8.8%), 247 (9.2%) and 275 (9%), of PAE were 177 (5.4%), 103 (3.8%) and 104 (6.4%) and of ABA were 144 (4.4%), 323 (12%) and 337 (11%), recpectively. Compared with 2019, KPN showed statistically significant trend of increasing resistance (p<0.001) after pandemic, mostly with meropenem (65.2%), ciprofloxacin (87.6%) and colistin (40.5%). CONCLUSIONS: COVID-19 might have caused increased prevalence and MDR of common pathogens, especially of KPN, which is probably due to the high percent of patients on the mechanical ventilation and prolonged hospital stay.http://www.sciencedirect.com/science/article/pii/S2213716524002236COVID-19antimicrobial resistancemulti-drug bacterial pathogensSerbia |
| spellingShingle | Predrag Savic Milos Gostimirovic Teodora Vitorovic Jovana Rajkovic Ana Bukarica Ljiljana Gojkovic-Bukarica The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia) Journal of Global Antimicrobial Resistance COVID-19 antimicrobial resistance multi-drug bacterial pathogens Serbia |
| title | The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia) |
| title_full | The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia) |
| title_fullStr | The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia) |
| title_full_unstemmed | The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia) |
| title_short | The influence of COVID-19 on the incidence and antimicrobial resistance of multi-drug resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in a tertiary care hospital in Belgrade (Serbia) |
| title_sort | influence of covid 19 on the incidence and antimicrobial resistance of multi drug resistant klebsiella pneumoniae pseudomonas aeruginosa and acinetobacter baumannii in a tertiary care hospital in belgrade serbia |
| topic | COVID-19 antimicrobial resistance multi-drug bacterial pathogens Serbia |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524002236 |
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