Histopathological studies upon effects of zeranol on the reproductive system in male merino lambs
Zeranal has been used as anabolic agent in cattle and sheep, especially in recent years. The purpose of this study was to determine the effects of zeranal on the development and histopathological changes of reproductive organs of male merino lambs implanted with zeranaL<p> In this trial, tourt...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=721 |
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| Summary: | Zeranal has been used as anabolic
agent in cattle and sheep, especially in recent years.
The purpose of this study was to determine the effects of
zeranal on the development and histopathological changes
of reproductive organs of male merino lambs implanted
with zeranaL<p>
In this trial, tourty-five m ale merino lambs at 126 ±
8 days of age were used. These lambs were divided into
three groups. Each group consisted of 15 animals.
Group I and group II were implanted with 12 mg zeranal
subcutaneously the base of ear of lambs at the baginning
of trials. After that, the same dose of zeranal was
reimplanted to group II 40 days after first implantation.
The remaining 15 lambs were used as a control group.
Five lambs from each groups were slaughtered at 80,
120 and 160 days atter the trial.<p>
The implantation of zeranal to the lambs induced
histopathological changes in the genital tract, which included;
reduced seminiferous tubular diameter, delayed
spermatogenesis in the testes; increased interductal
connective tissue, adenomyosis, hyperplasia and intraepithelial
lumina in the epididymides; squamous metaplasia,
cystic dilatation of same acini, keratinisation, hyperplasia
and increase in connective tissue in the prestat and
bulbourethral gland; reduced alveolar development and
an increase in connective tissue, alveoler cystic dilatation
in vesicular gland.<p>
lt may be concluded that zeranal induced changes
in the testes was reversible, whereas changes in
epididymides, prostat, bulbourethral and vesiculer gland
were irreversible. For this reason, zeranal implanted
lambs should not be used for breeding purpose. |
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| ISSN: | 1309-6958 2146-1953 |