Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects
Prostate cancer (PCa) is a major health concern that necessitates appropriate diagnostic approaches for timely intervention. This review critically evaluates the role of liquid biopsy techniques, focusing on blood- and urine-based biomarkers, in overcoming the limitations of conventional diagnosti...
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| Format: | Article |
| Language: | English |
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Korean Society for Sexual Medicine and Andrology
2025-01-01
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| Series: | The World Journal of Men's Health |
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| _version_ | 1841561274603798528 |
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| author | Yutong Liu Koji Hatano Norio Nonomura |
| author_facet | Yutong Liu Koji Hatano Norio Nonomura |
| author_sort | Yutong Liu |
| collection | DOAJ |
| description | Prostate cancer (PCa) is a major health concern that necessitates appropriate diagnostic approaches for timely intervention.
This review critically evaluates the role of liquid biopsy techniques, focusing on blood- and urine-based biomarkers, in overcoming
the limitations of conventional diagnostic methods. The 4Kscore test and Prostate Health Index have demonstrated
efficacy in distinguishing PCa from benign conditions. Urinary biomarker tests such as PCa antigen 3, MyProstateScore,
SelectMDx, and ExoDx Prostate IntelliScore test have revolutionized risk stratification and minimized unnecessary biopsies.
Emerging biomarkers, including non-coding RNAs, circulating tumor DNA, and prostate-specific antigen (PSA) glycosylation,
offer valuable insights into PCa biology, enabling personalized treatment strategies. Advancements in non-invasive liquid biomarkers
for PCa diagnosis may facilitate the stratification of patients and avoid unnecessary biopsies, particularly when PSA
is in the gray area of 4 to 10 ng/mL. |
| format | Article |
| id | doaj-art-86a3c9fd8bc848dc84e1aaf5f1d415e7 |
| institution | Kabale University |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-86a3c9fd8bc848dc84e1aaf5f1d415e72025-01-03T02:39:05ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-01-0143182710.5534/wjmh.230386Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging ProspectsYutong Liu0https://orcid.org/0009-0009-3844-9456Koji Hatano1https://orcid.org/0000-0002-8409-5152Norio Nonomura2https://orcid.org/0000-0002-6522-6233Department of Urology, Osaka University Graduate School of Medicine, Suita, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Suita, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Suita, JapanProstate cancer (PCa) is a major health concern that necessitates appropriate diagnostic approaches for timely intervention. This review critically evaluates the role of liquid biopsy techniques, focusing on blood- and urine-based biomarkers, in overcoming the limitations of conventional diagnostic methods. The 4Kscore test and Prostate Health Index have demonstrated efficacy in distinguishing PCa from benign conditions. Urinary biomarker tests such as PCa antigen 3, MyProstateScore, SelectMDx, and ExoDx Prostate IntelliScore test have revolutionized risk stratification and minimized unnecessary biopsies. Emerging biomarkers, including non-coding RNAs, circulating tumor DNA, and prostate-specific antigen (PSA) glycosylation, offer valuable insights into PCa biology, enabling personalized treatment strategies. Advancements in non-invasive liquid biomarkers for PCa diagnosis may facilitate the stratification of patients and avoid unnecessary biopsies, particularly when PSA is in the gray area of 4 to 10 ng/mL.biomarkersdiagnosisliquid biopsyprostate-specific antigenprostatic neoplasms |
| spellingShingle | Yutong Liu Koji Hatano Norio Nonomura Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects The World Journal of Men's Health biomarkers diagnosis liquid biopsy prostate-specific antigen prostatic neoplasms |
| title | Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects |
| title_full | Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects |
| title_fullStr | Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects |
| title_full_unstemmed | Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects |
| title_short | Liquid Biomarkers in Prostate Cancer Diagnosis: Current Status and Emerging Prospects |
| title_sort | liquid biomarkers in prostate cancer diagnosis current status and emerging prospects |
| topic | biomarkers diagnosis liquid biopsy prostate-specific antigen prostatic neoplasms |
| work_keys_str_mv | AT yutongliu liquidbiomarkersinprostatecancerdiagnosiscurrentstatusandemergingprospects AT kojihatano liquidbiomarkersinprostatecancerdiagnosiscurrentstatusandemergingprospects AT noriononomura liquidbiomarkersinprostatecancerdiagnosiscurrentstatusandemergingprospects |